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A STUDY ON EFFECTS OF GLUTATHIONE S-TRANSFERASE FROM SILKWORM ON CCL4-INDUCED MOUSE LIVER INJURY

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dc.contributor.author YAN, HUI
dc.contributor.author WANG, BOCHU
dc.contributor.author GUI, ZHONGZHENG
dc.date.accessioned 2022-12-01T05:02:27Z
dc.date.available 2022-12-01T05:02:27Z
dc.date.issued 2011-01-01
dc.identifier.citation Yan, H., Gui, Z., & Wang, B. (2011). A study on effects of glutathione S-transferase from silkworm on [CCl. sub. 4]-induced mouse liver injury. Pakistan Journal of Pharmaceutical Sciences, 24(1), 1-6. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14327
dc.description.abstract To assess the hepatoprotective activity of Glutathione S-transferase(GSTsw), extracted and purified from silkworm, in experimental acute mice liver injury and explore mechanisms. Mice were divided into five groups: control group, carbon tetrachloride (CCl4) group, and three treatment groups that received CCl4 and GSTsw at doses of 0.083mg•g-1, 0.0415 mg•g-1 and 0.0207 mg•g-1 for 3 days. ALT in serum, GST, SOD and T-AOC in liver tissue homogenate, and changes in liver pathology in the five groups were studied. CCl4 administration led to pathological and biochemical evidence of liver injury as compared to untreated controls. GSTsw administration led to significant protection against CCl4-induced changes in liver pathology. It was also associated with significantly lower serum ALT levels, higher GST SOD and T-AOC level in live tissue homogenate. Thus, GSTsw showed protective activity against CCl4-induced hepatotoxicity in mice. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Glutathione S-transferase en_US
dc.subject Bombyx mori en_US
dc.subject liver injury en_US
dc.subject carbon tetrachloride en_US
dc.title A STUDY ON EFFECTS OF GLUTATHIONE S-TRANSFERASE FROM SILKWORM ON CCL4-INDUCED MOUSE LIVER INJURY en_US
dc.type Article en_US


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