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REVERSAL OF HALOPERIDOL-INDUCED MOTOR DEFICITS BY MIANSERIN AND MESULERGINE IN RATS

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dc.contributor.author SHIREEN, ERUM
dc.contributor.author J. HALEEM, DARAKHSHAN
dc.date.accessioned 2022-12-01T05:07:12Z
dc.date.available 2022-12-01T05:07:12Z
dc.date.issued 2011-01-02
dc.identifier.citation Shireen, E., & Haleem, D. J. (2011). Reversal of haloperidol-induced motor deficits by mianserin and mesulergine in rats. Pak J Pharm Sci, 24(1), 7-12. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14328
dc.description.abstract Although haloperidol is widely prescribed for the treatment of schizophrenia, its beneficial effects are accompanied by extrapyramidal side effects (EPS). Role of 5-HT-2A/2C receptors in the attenuation of acute Parkinsonian-like effects of typical antipsychotics is investigated by prior administration of mianserin and mesulergine to rats injected with haloperidol. In the first part of study effects of various doses of haloperidol (0.5, 1.0, 2.5 and 5.0 mg/kg) were determined on motor activity and a selected dose (1 mg/kg) was used to monitor attenuation of parkinsonian effects by two different doses of 5-HT-2A/2C receptor antagonists mianserin (2.5 & 5.0 mg/kg) and mesulergine (1.0 & 3.0 mg/kg). Rats treated with haloperidol at doses of 0.5- 5.0 mg/kg exhibited impaired motor coordination and a decrease in exploratory activity in an open field. The dose response curve showed that at a dose of 1 mg/kg significant and submaximal effects are produced on motor coordination and exploratory activity. Coadministration of mianserin and mesulergine attenuated and reversed haloperidol-induced motor deficits in a dose dependent manner. The mechanism involved in the attenuation / reversal of haloperidol-induced parkinsonian like symptoms by mianserin and mesulergine is discussed. Prior administration of mianserin or mesulergine may be of use in the alleviation of EPS induced by conventional antipsychotic drugs. The findings have potential implication in the treatment of schizophrenia and motor disorders. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Mianserin, Mesulergine en_US
dc.subject Haloperidol en_US
dc.subject Exploratory activity en_US
dc.subject Extrapyramidal symptoms en_US
dc.subject Motor coordination. en_US
dc.title REVERSAL OF HALOPERIDOL-INDUCED MOTOR DEFICITS BY MIANSERIN AND MESULERGINE IN RATS en_US
dc.type Article en_US


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