• REVIEW MicroRNAs: A new paradigm towards mechanistic insight of diseases 

  Asif Nadeem; Muhammad Rizwan Ashraf; Maryam Javed; Tanveer Hussain; Muhammad Salman Tariq; Masroor Ellahi Babar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-10-04)

  : In 1993 miRNAs were discovered during a research on Caenorhabditis elegans conducted by Victor Ambros and Gary Ruvkun. The gene lin-4 that played important role in development in C. elgans was observed not encoding any ...
• MINI REVIEW Epigenetics: Quest for no-escape to HIV, a persistent pathogen 

  Bhatti, Muhammad Umar; Haseeb Amir Riaz; Bushra Tabassum; Nida Toufiq; Khan, Anwar; Muhammad Tariq; Iqra Yousaf; Imtiaz Ahmad Sajid; Mariam Shahid; Maryam Zameer (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-10-03)

  Acquired Immune Deficiency Syndrome (AIDS) is a disease infection mix, which is primarily because of 'deficient' immune system. Human Immune-deficiency Virus (HIV) makes the immune system susceptible to many infections ...
• REPORT Physicochemical and Antimicrobial properties of canola (Brassica napus L.) seed oil 

  Nazima Batool; Muhammad Arshad; Fayyaz-ul-Hassan; Noshin Ilyas; Armghan Shahzad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-10-02)

  Canola oil has been used in the Pakistan for the treatment of various diseases and skin infections. Oil was extracted with n-hexane from the seeds of canola (Brassica napus L.) and was evaluated for free fatty acid value. ...
• REPORT Ouabain inhibits RAW264.7 cells proliferation and induces apoptosis via Bcl-2 and bax expression 

  Luo, Yi; Qin, Hongxia; Zhao, Lin; Jin, Long; Jiang, Anan; Li, Xuewei; Li, Mingzhou; Wang, Xun (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-10-01)

  Ouabain is used in the clinical treatment of the cardiovascular diseases and it can be extensively investigated due to its promising pharmacological, pathological, and physiological properties. The present study is aimed ...
• REPORT Model studies of transmembrane interaction of FcεRIα/FcRγ reveal novel strategies to inhibit allergic responses 

  Asifa Majeed; Amir Rashid; Birgit Helm (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-30)

  The high-affinity IgE receptor complex plays an essential part in allergic responses and involved in downstream signaling, released inflammatory mediators that cause allergic responses. The transmembrane region of the ...
• Knowledge of modes of HIV transmission among public secondary school students in urban and rural areas in Malaysia 

  Khan, Muhammad Anwar Nawab; Nurul Aida Md Rosly; Abu Bakar Abdul Majeed; Nahlah Elkudssiah Ismail (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-29)

  The school students are of particular importance in the HIV/AIDS awareness policies at both local and international level. This study was conducted to assess the level of knowledge of the modes of HIV transmission among ...
• Pharmacological studies of Adhatoda vasica and Calotropis procera as resource of bio-active compounds for various diseases 

  Waseem Ahmed; Rafia Azmat; Khan, Shah Masaud; Khan, M Safeer; Abdul Qayyum; Ayaz Mehmood; Khan, Sami Ullah; Ijaz Hussain (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-28)

  Adhatoda vasica and Calotropis procera species were investigated as a resource for new diverse pharmacological agents including B complex, individual total phenolic compounds and antioxidants for curing and treatments of ...
• GC-MS profile of bioactive compounds from medicinally important Periploca hydaspidis 

  Rafi Ullah; Jehan Bakht; Mohammad Shafi; Muhammad Raza Shah (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-27)

  The aim of the present study was to investigate bioactive compounds in different solvent extracted samples from the stem tissues of P. hydaspidis using Gas Chromatography and Mass Spectroscopy techniques. GC-mass spectrum ...
• Effect of haloperidol on behavioral sensitization and cognition in methylphenidate and buspirone-methylphenidate co-administered rats 

  Nausheen Alam; Rahila Ikram (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-26)

  Attenuation of methylphenidate-induced behavioral sensitization and cognitive tolerance by buspirone coadministration has been reported previously. Dopamine D2-receptors are considered to be important in methylphenidateinduced ...
• Anti-inflammatory effect of the compounds from the flowers of Trollius chinensis 

  Liu, Li-Jia; Hu, Xiu-Hua; Guo, Li-Na; Wang, Ru-Feng; Zhao, Qi-Tao (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-25)

  In order to investigate the anti-inflammatory activity of flavonoids, phenolic acids, and alkaloids from the flowers of Trollius chinensis, some representative compounds, namely, orientin, 2"-O-β-L-galactopyranosylorientin, ...
• Effect of glycine: Studying memory and behavioral changes in mice 

  Samia Imtiaz; Mazhar Ayaz; Huma Ikram; Muhammad Imran Qadir; Syed Aun Muhammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-24)

  Glycine is an important chemical mediator of nervous system that plays a vital role in memory and other neurological functions. Therefore, the effect of glycine on these traits must be studied to understand biological mechanisms ...
• Supplementation of garlic and coriander seed powder: Impact on body mass index, lipid profile and blood pressure of hyperlipidemic patients 

  Falak Zeb; Mahpara Safdar; Sadia Fatima; Khan, Saleem; Sahib Alam; Mumtaz Muhammad; Ayesha Syed; Fozia Habib; Hira Shakoor (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-23)

  Garlic and coriander play an obligatory role in the metabolism of lipids leading to the reduction of CVD development. We hypothesized that garlic, coriander and their mixture improves the lipid profile, BMI and blood ...
• Analgesic and anti-inflammatory activities of the ethanol extract of Hibiscus rosa sinensis Linn (roots) 

  Zubia Begum; Ishrat Younus; Khan, Husna (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-23)

  The current study aimed to evaluate the analgesic and anti-inflammatory effects of the ethanolic extract of roots of Hibiscus rosa sinensis (HRS). The ethanolic extract was studied on tail flick test, acetic acid induced ...
• Spectrophotometric analysis of some metals and phytochemical screening of Digera muricata (Leaves and stems) 

  Isam Eldin Hussein Elgailani (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-21)

  The current research deals with estimation of the spectrophotometric analysis of some metals and phytochemical screening of the plant Digera muricata. The importance plant study arises from the fact that it has both ...
• Antileishmanial, insecticidal and phytotoxic potential of leaves and stems of Rumex nervosus Vahl. 

  Khan, Rasool; Mohammed Mansour Quradha; Abdullah Qasem Saif; Jawad Ali; Abdur Rauf (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-20)

  Biological assays including; phytotoxicity, brine shrimp lethality, antileishmanial and insecticidal activities were carried out on crude methanolic extracts of stems and leaves of R. nervosus and their fraction namely; ...
• Pharmacological and phytochemical analysis of Bergenia ciliata leaf and rhizome extracts 

  Saiqa Yousaf; Ghazala Kaukab; Hina Gul; Nauman Khalid; Rehana Kausar; Haroon Ahmed; Huma Ajab; Muhammad Gulfraz (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-19)

  Antibacterial, antifungal, antioxidant, cytotoxic, and anti-haemolytic activity of various rhizome extracts of Bergenia ciliata were evaluated in this study. The results showed inhibition of the growth of all selected ...
• Development and evaluation of mucoadhesive buccal tablet containing metronidazole for the treatment of periodontitis and gingivitis 

  Sobia Razzaq; Sana Hanif; Muhammad Ali Syed; Javed Iqbal; Syed Saeed ul Hassan; Syed Atif Raza; Humayun Riaz; Farah Abid (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-18)

  The current study was designed to evaluate mucoadhesive buccal tablet containing metronidazole (MTZ) for local action aided by Hydroxypropylmethylcellulose K4M (HPMC) and Carbopol 940® (CP) as mucoadhesive polymers with ...
• Comparison of atherogenic index and lipid profiles in candidates for coronary artery bypass graft surgery versus normal people 

  Mahmood Hosseinzadeh Maleki; Maryam Mousavi; Toba Kazemi; Nahid Azdaki; Amir Rahmanian Sharifabad; Hoshyar, Reyhane (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-17)

  Information on incidence and risk factors of cardiovascular disease (CVD) is rare in the Middle East. This study aims to compare Iranian candidates for coronary artery bypass graft (CABG) surgery and healthy controls in ...
• Effect of solvent polarity and extraction time on in vitro antioxidant properties of Brassica oleracea Convar Capitata Var L. seeds 

  Ayesha Rauf; Haq Nawaz; Muhammad Aslam Shad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-16)

  Effect of solvent polarity and extraction time on antioxidant properties of Brassica oleracea seeds was optimized by response surface methodology using central composite design. A significant linear negative effect of ...
• Comparative analysis of various antimicrobial agents present in locally available mouthwashes against oral pathogens 

  Humerah Bano Shafiq; Uzma Amin; Sunil Nawaz (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-15)

  Oral cavity exhibits general health of the body and affects the quality of life. Poor hygienic conditions are associated with chronic and systemic diseases. There are almost 750 species of various microorganisms which ...

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