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Browsing Issue 05 by Title

Browsing Issue 05 by Title

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  • GC-MS profile of bioactive compounds from medicinally important Periploca hydaspidis 
    Rafi Ullah; Jehan Bakht; Mohammad Shafi; Muhammad Raza Shah (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-27)
    The aim of the present study was to investigate bioactive compounds in different solvent extracted samples from the stem tissues of P. hydaspidis using Gas Chromatography and Mass Spectroscopy techniques. GC-mass spectrum ...
  • Histopathological changes induced in liver, kidney, heart and pancreas of rabbits by prolonged oral cyanide exposure 
    Muhammad Avais; Khan, Muhammad Sarwar; Khan, Muhammad Arif; Kamran Ashraf; Zahoor-Ul- Hassan; Sajid Hameed; Khan, Jawaria Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-04)
    The aim of the present study was to determine the deleterious effects of prolonged oral cyanide insult on various organs and tissues in rabbits. For this purpose, 12 locally bred adult male rabbits were allocated into two ...
  • Hypolipidemic and antioxidant potential of bitter gourd (Momordica charantia L.) leaf in mice fed on a high-fat diet 
    He, Qingfeng; Li, Yanjie; Li, Hong; Zhang, Pingping; Zhang, Ailin; You, Lingling; Wu, Haiqing; Xiao, Ping; Liu, Jinfu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-09)
    The purpose of this study was to investigate the antioxidant and hypolipidemic potential of bitter gourd (BG) leaf ethanol extract (LE) in mice fed a high-fat diet (HFD). Fifty mice were randomly separated into five groups ...
  • Impact of different solvent extracts from leaves and fruits of Eucalyptus globulus on growth of different bacteria and fungi 
    Jehan Bakht; Saman Farid; Saman Farid; Mohammad Shaf (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-10)
    The present research investigates the antimicrobial activities of the samples extracted from the leaves and fruits of Eucalyptus globulus through disc diffusion susceptibility assay using 1, 2 and 3mg disc-1 concentrations. ...
  • In vitro efficacy of linezolid against vancomycin resistant Enterococci 
    Muhammad Shahbaz Hussain; Azfar Sattar; Mazhar Hussain (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-11)
    Vancomycin–resistance among Enterococci has been escalating in recent years in many countries. Linezolid, an oxazolidinone is one of the novel drug that promised effective therapy of infections caused by vancomycin-resistant ...
  • Knowledge of modes of HIV transmission among public secondary school students in urban and rural areas in Malaysia 
    Khan, Muhammad Anwar Nawab; Nurul Aida Md Rosly; Abu Bakar Abdul Majeed; Nahlah Elkudssiah Ismail (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-29)
    The school students are of particular importance in the HIV/AIDS awareness policies at both local and international level. This study was conducted to assess the level of knowledge of the modes of HIV transmission among ...
  • MINI REVIEW Epigenetics: Quest for no-escape to HIV, a persistent pathogen 
    Bhatti, Muhammad Umar; Haseeb Amir Riaz; Bushra Tabassum; Nida Toufiq; Khan, Anwar; Muhammad Tariq; Iqra Yousaf; Imtiaz Ahmad Sajid; Mariam Shahid; Maryam Zameer (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-10-03)
    Acquired Immune Deficiency Syndrome (AIDS) is a disease infection mix, which is primarily because of 'deficient' immune system. Human Immune-deficiency Virus (HIV) makes the immune system susceptible to many infections ...
  • Molecular typing and evaluation of Sidr honey inhibitory effect on virulence genes of MRSA strains isolated from catfish in Egypt 
    Enany, Mohamed Elsayed; Algammal, Abdelazeem Mohamed; Shagar, Gehan Ibrahim; Amr Mohamed Hanora; Elfei, Wael Kamel; Elshaffy, Noha Mohamed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-13)
    Fish represent a worldwide significant source of animal protein. In order to investigate the prevalence of MRSA in catfish as well as the inhibitory effect of Sidr honey on virulence genes of MRSA, fish were collected ...
  • Pharmacological and phytochemical analysis of Bergenia ciliata leaf and rhizome extracts 
    Saiqa Yousaf; Ghazala Kaukab; Hina Gul; Nauman Khalid; Rehana Kausar; Haroon Ahmed; Huma Ajab; Muhammad Gulfraz (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-19)
    Antibacterial, antifungal, antioxidant, cytotoxic, and anti-haemolytic activity of various rhizome extracts of Bergenia ciliata were evaluated in this study. The results showed inhibition of the growth of all selected ...
  • Pharmacological studies of Adhatoda vasica and Calotropis procera as resource of bio-active compounds for various diseases 
    Waseem Ahmed; Rafia Azmat; Khan, Shah Masaud; Khan, M Safeer; Abdul Qayyum; Ayaz Mehmood; Khan, Sami Ullah; Ijaz Hussain (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-28)
    Adhatoda vasica and Calotropis procera species were investigated as a resource for new diverse pharmacological agents including B complex, individual total phenolic compounds and antioxidants for curing and treatments of ...
  • Phytochemical screening and antioxidant potential of Parthenocissus quinquefolia (L.) planch extracts of bark and stem 
    Summiya Faisal; Anjum Perveen; Khan, Zaheer-ud-Din; Sardar, Andleeb Anwar; Shabnum Shaheen; Asma Manzoor (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-06)
    The phytochemical screening and antioxidant potential of bark and stem of Parthenocissus quinquefolia (L.) planch was assessed in order to verify its ethnopharmacological significance. All major secondary metabolites e.g. ...
  • Prunus domestica alters functions of frog’s heart 
    Talat Ahmed; Abida Shaheen; Fahad Azam; Waseem Safdar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-07)
    Prunes could exert cardiovascular protective effects. Trials have demonstrated antihypertensive effects of Prunus domestica. The aim of this study was to find out if prunes could alter cardiac functions that may ...
  • REPORT Model studies of transmembrane interaction of FcεRIα/FcRγ reveal novel strategies to inhibit allergic responses 
    Asifa Majeed; Amir Rashid; Birgit Helm (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-30)
    The high-affinity IgE receptor complex plays an essential part in allergic responses and involved in downstream signaling, released inflammatory mediators that cause allergic responses. The transmembrane region of the ...
  • REPORT Ouabain inhibits RAW264.7 cells proliferation and induces apoptosis via Bcl-2 and bax expression 
    Luo, Yi; Qin, Hongxia; Zhao, Lin; Jin, Long; Jiang, Anan; Li, Xuewei; Li, Mingzhou; Wang, Xun (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-10-01)
    Ouabain is used in the clinical treatment of the cardiovascular diseases and it can be extensively investigated due to its promising pharmacological, pathological, and physiological properties. The present study is aimed ...
  • REPORT Physicochemical and Antimicrobial properties of canola (Brassica napus L.) seed oil 
    Nazima Batool; Muhammad Arshad; Fayyaz-ul-Hassan; Noshin Ilyas; Armghan Shahzad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-10-02)
    Canola oil has been used in the Pakistan for the treatment of various diseases and skin infections. Oil was extracted with n-hexane from the seeds of canola (Brassica napus L.) and was evaluated for free fatty acid value. ...
  • REVIEW MicroRNAs: A new paradigm towards mechanistic insight of diseases 
    Asif Nadeem; Muhammad Rizwan Ashraf; Maryam Javed; Tanveer Hussain; Muhammad Salman Tariq; Masroor Ellahi Babar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-10-04)
    : In 1993 miRNAs were discovered during a research on Caenorhabditis elegans conducted by Victor Ambros and Gary Ruvkun. The gene lin-4 that played important role in development in C. elgans was observed not encoding any ...
  • Spectrophotometric analysis of some metals and phytochemical screening of Digera muricata (Leaves and stems) 
    Isam Eldin Hussein Elgailani (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-21)
    The current research deals with estimation of the spectrophotometric analysis of some metals and phytochemical screening of the plant Digera muricata. The importance plant study arises from the fact that it has both ...
  • Spectroscopic and cytotoxic studies of losartan complexes 
    Mansoor Ahmed; Mohsin Ali; Syed Imran Ali; Majid Mumtaz; Syed Moazzam Haider; Shakil Ahmed; Khan, Khalid Mohammed; Tanoli, Muhammad Asad Khan; Seyed Abdulmajid Ayatollahi; Nasir Ansar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-14)
    Use of drug-metal complexes for the treatment of several human diseases has resulted in significant progress in the field of medicinal inorganic chemistry. The current study describes the synthesis and characterization ...
  • Supplementation of garlic and coriander seed powder: Impact on body mass index, lipid profile and blood pressure of hyperlipidemic patients 
    Falak Zeb; Mahpara Safdar; Sadia Fatima; Khan, Saleem; Sahib Alam; Mumtaz Muhammad; Ayesha Syed; Fozia Habib; Hira Shakoor (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-23)
    Garlic and coriander play an obligatory role in the metabolism of lipids leading to the reduction of CVD development. We hypothesized that garlic, coriander and their mixture improves the lipid profile, BMI and blood ...
  • Synthesis, spectral analysis and antibacterial activity of some novel 5- substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4- oxadiazole derivatives 
    Aziz-ur-Rehman; Asia Siddiqa; Abbasi, Muhammad Athar; Sabahat Zahra Siddiqui; Khan, Samreen Gul; Shahid Rasool; Shah, Syed Adnan Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-02)
    A number of novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-Oxadiazole derivatives (6a-l) have been synthesized to evaluate their antibacterial activity. Using aryl/aralkyl carboxylic acids (1a-l) ...

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