Issue 05: Recent submissions

  • Spectroscopic and cytotoxic studies of losartan complexes 
    Mansoor Ahmed; Mohsin Ali; Syed Imran Ali; Majid Mumtaz; Syed Moazzam Haider; Shakil Ahmed; Khan, Khalid Mohammed; Tanoli, Muhammad Asad Khan; Seyed Abdulmajid Ayatollahi; Nasir Ansar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-14)
    Use of drug-metal complexes for the treatment of several human diseases has resulted in significant progress in the field of medicinal inorganic chemistry. The current study describes the synthesis and characterization ...
  • Molecular typing and evaluation of Sidr honey inhibitory effect on virulence genes of MRSA strains isolated from catfish in Egypt 
    Enany, Mohamed Elsayed; Algammal, Abdelazeem Mohamed; Shagar, Gehan Ibrahim; Amr Mohamed Hanora; Elfei, Wael Kamel; Elshaffy, Noha Mohamed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-13)
    Fish represent a worldwide significant source of animal protein. In order to investigate the prevalence of MRSA in catfish as well as the inhibitory effect of Sidr honey on virulence genes of MRSA, fish were collected ...
  • Analgesic, anti-inflammatory and diuretic activities of Macrotyloma uniflorum (Lam.) Verdc. 
    Javed Ashraf; Baig, Sadia Ghousia; Salman Ahmed; Muhammad Mohtasheemul Hasan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-12)
    Macrotyloma uniflorum (Lam.) Verdc. (Papilionaceae) is commonly known as Horse gram and Kulthi. The seeds are reported as anthelmintic, diaphoretic, diuretic and emmenagogue. It is also useful in asthma, bronchitis and ...
  • In vitro efficacy of linezolid against vancomycin resistant Enterococci 
    Muhammad Shahbaz Hussain; Azfar Sattar; Mazhar Hussain (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-11)
    Vancomycin–resistance among Enterococci has been escalating in recent years in many countries. Linezolid, an oxazolidinone is one of the novel drug that promised effective therapy of infections caused by vancomycin-resistant ...
  • Impact of different solvent extracts from leaves and fruits of Eucalyptus globulus on growth of different bacteria and fungi 
    Jehan Bakht; Saman Farid; Saman Farid; Mohammad Shaf (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-10)
    The present research investigates the antimicrobial activities of the samples extracted from the leaves and fruits of Eucalyptus globulus through disc diffusion susceptibility assay using 1, 2 and 3mg disc-1 concentrations. ...
  • Hypolipidemic and antioxidant potential of bitter gourd (Momordica charantia L.) leaf in mice fed on a high-fat diet 
    He, Qingfeng; Li, Yanjie; Li, Hong; Zhang, Pingping; Zhang, Ailin; You, Lingling; Wu, Haiqing; Xiao, Ping; Liu, Jinfu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-09)
    The purpose of this study was to investigate the antioxidant and hypolipidemic potential of bitter gourd (BG) leaf ethanol extract (LE) in mice fed a high-fat diet (HFD). Fifty mice were randomly separated into five groups ...
  • Development and optimization of intermediate release ketoprofen tablets by central composite design 
    Farya Zafar; Muhammad Harris Shoaib; Rabia Ismail Yousuf; Huma Ali; Rabia Bushra (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-08)
    In this study cost effective direct compression technique was used for the development and optimization of intermediate release (IntR) ketoprofen tablets using central composite design (CCRD). Fifteen different formulations ...
  • Prunus domestica alters functions of frog’s heart 
    Talat Ahmed; Abida Shaheen; Fahad Azam; Waseem Safdar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-07)
    Prunes could exert cardiovascular protective effects. Trials have demonstrated antihypertensive effects of Prunus domestica. The aim of this study was to find out if prunes could alter cardiac functions that may ...
  • Phytochemical screening and antioxidant potential of Parthenocissus quinquefolia (L.) planch extracts of bark and stem 
    Summiya Faisal; Anjum Perveen; Khan, Zaheer-ud-Din; Sardar, Andleeb Anwar; Shabnum Shaheen; Asma Manzoor (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-06)
    The phytochemical screening and antioxidant potential of bark and stem of Parthenocissus quinquefolia (L.) planch was assessed in order to verify its ethnopharmacological significance. All major secondary metabolites e.g. ...
  • Evaluation of the hepatic effect of concomitant administration of ciprofloxacin and some antimalarial drugs in Plasmodium berghei infected mice: An in vivo study 
    Amorha, Kosisochi Chinwendu; Ugwuowo, Onyinyechukwu Blessing; Ayogu, Ebere Emilia; Nduka, Sunday Odunke; Okonta, Mathew Jegbefume (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-05)
    This study evaluated the hepatotoxic effects of artesunate (AS), artemether-lumefantrine (AL) and artesunateamodiaquine (ASAQ) co-administration with ciprofloxacin (CIP) using animal model. Chloroquine sensitive Plasmodium ...
  • Histopathological changes induced in liver, kidney, heart and pancreas of rabbits by prolonged oral cyanide exposure 
    Muhammad Avais; Khan, Muhammad Sarwar; Khan, Muhammad Arif; Kamran Ashraf; Zahoor-Ul- Hassan; Sajid Hameed; Khan, Jawaria Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-04)
    The aim of the present study was to determine the deleterious effects of prolonged oral cyanide insult on various organs and tissues in rabbits. For this purpose, 12 locally bred adult male rabbits were allocated into two ...
  • Development and evaluation of immediate release diclofenac sodium suppositories 
    Tariq Sultan; Shaista Hamid; Sohail Hassan; Kanwal Hussain; Ateka Ahmed; Lubna Bashir; Shazia Naz; Tahmina Maqbool (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-03)
    The objective of present study was to develop and evaluate polyethylene glycol (PEG) based diclofenac sodium suppositories. This study used water soluble PEG bases (1000, 4000 and 6000) in different combinations to formulate ...
  • Synthesis, spectral analysis and antibacterial activity of some novel 5- substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4- oxadiazole derivatives 
    Aziz-ur-Rehman; Asia Siddiqa; Abbasi, Muhammad Athar; Sabahat Zahra Siddiqui; Khan, Samreen Gul; Shahid Rasool; Shah, Syed Adnan Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-02)
    A number of novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-Oxadiazole derivatives (6a-l) have been synthesized to evaluate their antibacterial activity. Using aryl/aralkyl carboxylic acids (1a-l) ...
  • Effect of isoespintanol isolated from Oxandra cf. xylopioides against DNA damage of human lymphocytes 
    Marquez-Fernandez Maria, Elena; Munoz-Lasso, Diana Carolina; Juan Bautista Lopez; Zapata, Karol; Mejia, Miguel Angel Puertas; Alarcon, Camilo Lopez; Rojano, Benjamin Alberto (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-01)
    Synthetic antioxidants are used in the food and pharmaceutical industry, however, there is concern about their safety; this has prompted the search for new antioxidants that are effective, safe and act at low concentrations. ...

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