• Synthesis of novel thiazolyl-phenyl-thiazole derivatives as promising anti-Candida agents 

  Borcea, Anca-Maria; Marc, Gabriel; Vodnar, Dan C; Vlase, Laurian; Oniga, Ovidiu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-09)

  New imine derivatives, that contain the thiazolyl-phenyl-thiazole scaffold, were synthesized and evaluated as anti-Candida agents. Elemental analysis and FT-IR, MS, 1 H-NMR and 13C-NMR spectroscopic methods confirmed the ...
• Effects of methanolic and aqueous extracts of Ipomoea batatas L on mineral contents level (calcium and magnesium) in alloxan-induced diabetic rats 

  Imtiaz Mahmood Tahir; Naheed Akhter; Abida Parveen; Huma Mehboob; Sadaf Saleem; Naveed Munir; Shah, Syed Muhammad Ali; Jawad Zaheer; Khan, Fahad Said; Sabira Sultana; Muhammad Akram (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-08)

  In diabetic patients, electrolyte disorders frequently occur with the characteristic changes in minerals like calcium and magnesium etc. Several medicines are used to manage diabetes mellitus but they exert adverse effects. ...
• Cyclodextrin-based nanosponge for improvement of solubility and oral bioavailability of Ellagic acid 

  Fatma Mohammed Mady; Sabrin Ragab Mohamed Ibrahim (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-07)

  Ellagic acid (EA) is a polyphenolic compound, naturally occurring in various fruits. It has antioxidant, anticancer and antimutagenic properties. Its low aqueous solubility and permeability in GIT, permanent binding to ...
• Hepatoprotective and hepatocurative effects of Spilanthes acmella Murr against paracetamol induced hepatotoxicity 

  Shah, Syed Nisar Hussain; Asma Mumtaz; Chaudary, Muhammad Zabta; Nauman Bashir; Muhammad Mazhar Ayaz; Faheem Ahmad Siddique; Khizar Abbas (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-06)

  Hepatotoxicity is appreciably escalating health dilemma worldwide and the degree of the problem has encouraged importance in the exploration for hepatotherapeutic agents from plants. In the current research work, the ...
• Pharmacokinetic and tissue distributions study of adenosine, 4- hydroxybenzyl alcohol and Parishin C from Gastrodia elata extract in rats 

  Bing, Wang; Tao, Sun Yan; Zhi-Dong, Pei; Ting-Guo, Kang; Hui, Zhang (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-05)

  The plant Gastrodia elata is a type of the orchid plant Gastrodia elata Bl. which contains glycosides, phenols, polysaccharides, sterols, and organic acids and a variety of active ingredients are proved to have certain ...
• Flagellar motility plays important role in Biofilm formation of Bacillus cereus and Yersinia enterocolitica 

  Iram Liaqat; Mirza, Safdar Ali; Riffat Iqbal; Nazish Mazhar Ali; Gulbeena Saleem; Samia Majid; Maryam Shahid (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-04)

  Bacteria live either independently as planktonic cells or in organized surface associated colonies called as biofilms. Biofilms play an important role in increased pathogenesis of bacteria and it is assumed that motility ...
• A study of retinopathy analysis in type 2 diabetes patients in Chinese population 

  Zheng, Xuedong; Zhang, Liang (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-03)

  In this investigation, the risk factor that arises from diabetic retinopathy was assessed in type 2 diabetes patients. The study is based on a 5-year community-based program, which comprises of 750 participants of the ...
• To evaluate the efficacy and safety of CartiNovex plus tablet in osteoarthritis and rheumatoid arthritis 

  Amir Riaz; Muhammad Daniyal; Muhammad Ishaq Ghauri; Hamza Alam; Syed Faisal Zaidi; Khan Usmanghani; Wei Wang (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-02)

  Interminable arthritis issue, for example, osteoarthritis (OA) and rheumatoid arthritis (RA) have in like manner an upsurge of aggravation, and oxidative anxiety, bringing about dynamic histological modifications and ...
• The anemonin content of four different Ranunculus species 

  Neag, Teodora; Olah, Neli-Kinga; Hanganu, Daniela; Benedec, Daniela; Pripon, Flavia Furtuna; Ardelean, Aurel; Toma, Claudia Crina (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-01)

  The Ranunculus species are poorly known as medicinal plants. They have potential toxicity given by the ranunculin and its enzymatic degradation compounds: protoanemonin and anemonin. This paper aims to evaluate the anemonin ...
• Administration of 5-HT-1B agonist ameliorates pseudodementia induced by depression in rats 

  Asia Afzal; Saara Ahmad; Faiza Agha; Zehra Batool; Saiqa Tabassum; Laraib Liaquat; Sadia Sadir; Amber Nawaz; Saida Haider (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-23)

  Major depressive disorder (MDD) is the leading cause of memory impairment in general population. The serotonin hypothesis provides a target model for the treatment of depression and depression-associated memory loss. 5- ...
• Development of quality standard and phytochemical analysis of Carica papaya Linn leaves 

  Syed Zohaib Hussain; Nighat Razvi; Syed Imran Ali; Syed Mohammad Farid Hasan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-22)

  Carica papaya Linn is the member of Caricaceae family of Kingdom Plantae. The study was executed for the development of qualitative standards of male and female leaves of the plant. The study included evaluation ...
• Determination of anti-oxidative, anti-microbial activity and heavy metal contents of Leucoagaricus leucothites 

  Mustafa Sevindik; Azhar Rasul; Ghulam Hussain; Haseeb Anwar; Muhammad Kashif Zahoor; Iqra Sarfraz; Kashif Shahid Kamran; Hasan Akgul; Ilgaz Akata; Zeliha Selamoglu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-21)

  Mushrooms, a treasure of diverse bioactive scaffolds, have been widely admired due to their nutritional and medicinal significance all over the world. The current study intended to evaluate the therapeutic potentiality ...
• Dexibuprofen: Statistical assessment of drug release kinetics and investigative quality perspective 

  Anas M Hanif; Ali Akbar Sial; Huma Ali; Farya Zafar; Mirza Tasawar Baig; Rabia Bushra; Khan, Maqsood Ahmed; Amber Nawab; Omer Mustapha; Shumaila Shafique (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-20)

  Healthcare professionals including physicians and pharmacists have been trying since long to come across and work out regarding the issue of generic alternatives, which is highly affected by factors like therapeutic efficacy, ...
• Impact of Colocasia esculenta extract and fractions on high-fat dietinduced changes in body weight, adipose tissue and liver of rats 

  Azubuike, Nkiruka Chinonyelum; Onwukwe, Okechukwu Steven; Onyemelukwe, Anulika Obianuju; Maduakor, Uzoamaka Charity; Ifeorah, Ijeoma Maryjoy; Okwuosa, Chukwugozie Nwachukwu; Achukwu, Peter Uwadiegwu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-19)

  The objective of the present study was to explore on the possible protective effects of the saponins and alkaloid-rich fractions of Colocasia esculenta L. Schott leaves on high-fat diet-induced changes in rats. High-fat ...
• Assessment of killing kinetics assay and bactericidal mechanism of crude methanolic bark extract of Casuarina equisetifolia 

  Yousra Shafiq; Syed Baqir Shyum Naqvi; Ghazala H Rizwani; Tanveer Abbas; Huma Sharif; Huma Ali; Muhammad Arif Asghar; Rabia Bushra; Farya Zafar; Saima Abdein; Ambreen Huma (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-18)

  Casuarina equisetifolia L. is an important medicinal plant widely used to treat various diseases particularly ulcers, diabetes, cough, diarrhea and many infectious and skin diseases. The aim of this research study was to ...
• Renoprotective effects of Silybum marianum (L.) Gaertn (Silymarin) on thioacetamide-induced renal injury: Biochemical and histopathological approach 

  Cengiz, Mustafa (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-17)

  Thioacetamide (TAA), recognized as an experimental toxin, mainly causes acute liver damage through the production of free radicals. TAA as well induces renal dysfunction hence; renal failure is often related with the ...
• Effect of Lactobacillus casei on serum interleukins following enteropathogenic E. coli infection in experimental rabbits 

  Iqra Fayyaz; Muhammad Asif Zahoor; Muhammad Shahid; Muhammad Hidayat Rasool; Zeeshan Nawaz (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-16)

  In the present study we investigated the pro-inflammatory and anti-inflammatory effect of Lactobacillus casei following infection with multi-drug resistant enteropathogenic Escherichia coli infection in experimental ...
• Aloe vera extract: A novel antimicrobial and antibiofilm against methicillin resistant Staphylococcus aureus strains 

  Amna Ali Saddiq; Huda Al-Ghamdi (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-15)

  Bacterial infectious maladies are the leading cause of death worldwide. Microbial drug resistance boosts the severity of the maladies. In the present study, the antibacterial impact of Aloe vera leaf aqueous extract against ...
• Potential anti-inflammatory effect of Cissus quadrangularis L. and Lepedium sativum L. along with their combination extracts 

  Amir Shadmani; Ghazala H Rizwani; Maryam Ahmed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-14)

  The anti inflammatory activity of methnolic root extract of Cissus quadrangularis L. (CQ) and seed extract of Lepedium sativum L. (LS) were studied in rats also in conjunction with using a mixture (CL) of CQ and LS. ...
• 6-shogaol protects against diabetic nephropathy and cardiomyopathy via modulation of oxidative stress/NF-κB pathway 

  Waleed H Al Malki; Ihab T Abdel-Raheem; Mohamed Z Dawoud; Randa F Abdou (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-09-13)

  Diabetes dramatically increases the risk of numerous heart and kidney troubles. Diabetic nephropathy (DN) and cardiomyopathy (DC) are major causes of death. The pathophysiology of DN/DC includes inflammatory and oxidative ...

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