Abstract:
The objective of the present study was to investigate the antinociceptive and anti-hyperglycemic activity of
methanolic leaf extract of Cyperus scariosus. Antinociceptive activity was determined using a model of acetic
acid-induced gastric pain in mice and anti-hyperglycemic activity through glucose tolerance test using glucose
loaded mice. In writhing assays induced by acetic acid, the methanolic leaf extract showed dose dependent
significant pain inhibition compared to control. The maximum writhing inhibition (46.62%) was found at a dose
of 200 mg/kg body weight which was less than that of the positive control, aspirin (56.74%), when used at the
same dose. Anti-hyperglycemic activity of the extract was also found to be significant in mice loaded with
glucose at doses of 200 and 400 mg/kg body weight. Maximum tolerance (42.86%) was showed at 400 mg
extract/kg body weight, which compared favorably with that of glibenclamide at 10 mg/kg body weight
(57.62%). In summary, the methanol extract of C. scariosus leaves has had beneficial effects as a pain reliever
and also in reducing the elevated blood glucose level of hyperglycemic mice.
