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THERAPEUTIC EFFECTS OF CIPROFLOXACIN ON THE PHARMACOKINETICS OF CARBAMAZEPINE IN HEALTHY ADULT MALE VOLUNTEERS

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dc.contributor.author SHAHZADI, ANDLEEB
dc.contributor.author JAVED, IJAZ
dc.contributor.author ASLAM, BILAL
dc.contributor.author MUHAMMAD, FAQIR
dc.contributor.author RAFIQUE ASI, MUHAMMAD
dc.contributor.author YASIN ASHRAF, MUHAMMAD
dc.contributor.author RAHMAN, ZIA-UR
dc.date.accessioned 2022-12-01T05:43:08Z
dc.date.available 2022-12-01T05:43:08Z
dc.date.issued 2011-01-12
dc.identifier.citation Shahzadi, A., Javed, I., Aslam, B., Muhammad, F., Asi, M. R., Ashraf, M. Y., & Ur-Rahman, Z. (2011). Therapeutic effects of ciprofloxacin on the pharmacokinetics of carbamazepine in healthy adult male volunteers. Pak J Pharm Sci, 24(1), 63-68. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14360
dc.description.abstract Carbamazepine is a (CYP1A2 and CYP3A4 enzyme inducer) medicine which is used by epileptic patients for a long time. During the course of therapy, patients are generally caught by other diseases like urinary tract infections, upper respiratory tract infection, skin and soft tissue infection etc. To cure them, physicians commonly prescribe fluoroquinolones like Ciprofloxacin (CYP1A2 inhibitor) along with Carbamazepine (CBZ). Interactions may result without recognition which may lead to unforeseen toxicity, untoward effects or even therapeutic failure. Therefore, studies were conducted to investigate the effect of Ciprofloxacin on the pharmacokinetics of carbamazepine in healthy adult male volunteers. The main objective of this study was to generate new knowledge regarding CBZ and ciprofloxacin interaction for physicians and research workers dealing with these medicines. Eight healthy adult male volunteers were selected to assess the effect of ciprofloxacin on the pharmacokinetics of carbamazepine. After overnight fast the selected male volunteers were given CBZ orally. Blood samples were drawn at different time intervals after medication. Then the same volunteers were given CBZ along with ciprofloxacin. Blood samples were again drawn at the same time intervals as done previously. Plasma was separated from the blood samples. Concentration of CBZ in the plasma samples was determined by using HPLC technique. Results of the present study indicated that ciprofloxacin significantly increased the plasma concentration of CBZ when given concurrently to the healthy adult male volunteers. Ciprofloxacin increased Cmax, AUC and t ½ while it decreased the CL and Vd of CBZ when administered concurrently to the adult volunteers. Change in pharmacokinetic parameters was due to slow metabolism or elimination of CBZ when given concurrently with ciprofloxacin to the adult volunteers. This is probably due to the inhibition of CYP3A4 isoenzyme by ciprofloxacin which is responsible for metabolism of CBZ. Ciprofloxacin increased the plasma concentration of CBZ so dose adjustment as well as drug monitoring of CBZ is required when both the drugs are given concurrently. The knowledge regarding interaction between ciprofloxacin and CBZ would be helpful for the pharmaceutical industries, physicians and a blessing for the patients. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Carbamazepine en_US
dc.subject Ciprofloxacin en_US
dc.subject Cytochrome en_US
dc.subject Maximum plasma concentration of drug en_US
dc.subject Area under curve and half life en_US
dc.subject clearance and volume of distribution. en_US
dc.title THERAPEUTIC EFFECTS OF CIPROFLOXACIN ON THE PHARMACOKINETICS OF CARBAMAZEPINE IN HEALTHY ADULT MALE VOLUNTEERS en_US
dc.type Article en_US


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