Abstract:
Emergence of multi-drug resistant (MDR) and extensively drug resistant (XDR) TB throughout the developing
world is very disturbing in the present scenario of TB management. There is a fundamental need to explore
alternative anti-TB agents. Hence natural plants should be investigated to understand their antimicrobial
properties and safety. Garlic (Allium sativum) is one of natural plant which possesses variety of biological
properties like anti-tumor, anti-hyperlipedemic and anti-microbial etc. The present study was evaluated for antibacterial activity of garlic against non-MDR and MDR isolates of M. tuberculosis. A total of 20 clinical isolates of MTB including 15 MDR and 5 non-MDR were investigated. Ethanolic extract of garlic was prepared by maceration method. Minimum inhibitory concentration (MIC) was performed by using 7H9 middle brook broth dilution technique. MIC of garlic extract was ranged from 1 to 3 mg/ml; showing inhibitory effects of garlic
against both non-MDR and MDR M. tuberculosis isolates. Alternate medicine practices with plant extracts
including garlic should be considered to decrease the burden of drug resistance and cost in the management of diseases. The use of garlic against MDR-TB may be of great importance regarding public health.
