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REACTIONS OF PHTHALIMIDES WITH 1-METHYLETHYLAMINE: ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF RESULTING CARBOXAMIDES
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| dc.contributor.author | OKUNROBO, L. O. | |
| dc.contributor.author | USIFOH, C. O. | |
| dc.contributor.author | OKPO, S. O. | |
| dc.date.accessioned | 2022-12-01T07:59:36Z | |
| dc.date.available | 2022-12-01T07:59:36Z | |
| dc.date.issued | 2006-01-07 | |
| dc.identifier.citation | Okunrobo, L. O., Usifoh, C. O., & Okpo, S. O. (2006). Reactions of phthalimides with 1-methylethylamine: analgesic and anti-inflammatory properties of resulting carboxamides. Pak. J. Pharm. Sci, 19(1), 28-34. | en_US |
| dc.identifier.issn | 1011-601X | |
| dc.identifier.uri | http://142.54.178.187:9060/xmlui/handle/123456789/14409 | |
| dc.description.abstract | The reaction of phthalimide derivatives (1a-c) with 1-methylethylamine in dimethylformamide (DMF) at room temperature afforded benzamido-N-prop-2-ynyl-2-(2-methylethyl)-carboxamide (3a), benzamido-N-cyclopentyl-2- (2-methylethyl)-car-boxamide (3b) and benzamido-N-benzyl-2-(2-methylethyl)-carboxamide (3c), respectively. In the carrageenan induced paw oedema test for anti-inflammatory activity, 3a (50 mg/kg) decreased the inflammatory response by 55% after 3 hrs while 3b and 3c exhibited significant reduction in the oedema level. The compounds 3a, 3b and 3c exhibited analgesic activities with 3b producing 76% inhibition. The activities were dose – dependent. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi | en_US |
| dc.subject | Carboxamides | en_US |
| dc.subject | synthesis | en_US |
| dc.subject | analgesic activity | en_US |
| dc.subject | rat paw oedema | en_US |
| dc.title | REACTIONS OF PHTHALIMIDES WITH 1-METHYLETHYLAMINE: ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF RESULTING CARBOXAMIDES | en_US |
| dc.type | Article | en_US |
