• REVIEW Therapeutic potential of carbonic anhydrase inhibitors 

  Rahman, Shafiq-ur-; Bib, Sumbal; Javed, Tariq; Alam, Fiaz; Atif Ali, Zia ur Rehman; Quresh, Sayyad; Ali, Majeed; Ullah, Muhammad Hassham Hassan Bin; Asad, Syed Muhammad; Hasan, Farid; Sabatier, Jean-Marc; Rizvanov, Albert A (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-04-02)

  Enzymes are biological catalyst involve in different biochemical reactions. But over activation of these biomolecules can cause disease thus different inhibitors and knockout therapies are use in current clinical practice. ...
• MINI REVIEW Wound healing potential of edible plants 

  Katyakyini Muniandy; Sivapragasam Gothai; Palanisamy Arulselvan; Subbiah Suresh Kumar; Mohd Esa Norhaizan; Arthanari Umamaheswari; Sharida Fakurazi (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-04-01)

  Wound healing is a natural intricate cascade process involving cellular, biochemical and molecular mechanism to restore the injured or wounded tissue. Malaysia's multi-ethnic social fabric is reflected in its different ...
• REPORT Interactions and conflicts of interests between prescribers and medical sales representatives (MSRs) regarding prescribing and drug promotion practices in Karachi, Pakistan 

  Naqvi, Atta Abbas; Zehra, Fatima; Khan, Nabeel; Ahmad, Rizwan; McGarry, Ken (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-31)

  Pharmaceutical drug promotion practices are found to have potentially controversial ethical standards. They may compromise on patient’s wellbeing especially when it inordinately affects the clinical care and patient’s ...
• REPORT Laparoscopic management for coexistent parasitic ovarian teratoma of the omentum and ovarian mucinous cystadenoma: A case report 

  Huang, Chen-Ching; Koh, Lim-Woh (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-29)

  We report a case of a 34-year-old woman who underwent laparoscopy for her adnexal tumor. Coexistence of ovarian mucinous cystadenoma and parasitic ovarian teratoma of the omentum was found and successfully treated by ...
• Evaluation of anticonvulsant and antiepileptogenic activity of Euphorbia nivulia in PTZ-induced kindling model of epilepsy in mice 

  Rehman, Agha Habibur; Sharar, Shakir D Al; Ahmad, Mahmood; Akhtar, Muhammad; Khan, Younus; Ashra, Muhammad Nadeem (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-28)

  Epilepsy rema ins a major chronic neurological disorder with significantly higher refractory seizure rate. Based on the folk medicine literature, we explored the anticonvulsant and antiepileptogenic activity of aqueous ...
• Preparation and in vivo evaluation of sodium alginate - poly (vinyl alcohol) electrospun nanofibers of forskolin for glaucoma treatment 

  Yellanki, Shiva Kumar; Anna, Balaji; Kishan, Marupaka Radha (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-27)

  The present investigation is aiming to prepare Sodium Alginate (SA) - Poly (vinyl alcohol) (PVA) nanofibrous mats of Forskolin (FSK) for ocular delivery to treat the glaucoma. Nanofibers of SA: PVA (1:0.25) load with β- ...
• Phytochemical investigation of Hyoscyamus albus 

  Muhammad Ashraf; Manzoor Ahmad; Hanif Ahmad; Shujaat Ahmad (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-26)

  The work presented in this paper illustrates the isolation and structure elucidation of secondary metabolites of Hyoscyamus albus. Two new natural source and three known compounds were isolated from the Hyoscyamus albus. ...
• Protein chip analysis of cytokines reveals a key mechanism of the antitumor and immunostimulatory activities of Tricholoma matsutake polysaccharide 

  Ding, Xiang; Zhang, Nan; Hou, Yiling; Zhu, Hongqing (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-25)

  Polysaccharide has been widely used in medical and health field because of its function of immune regulation. The aim of present study was to use protein chip to test the 200 cytokines secreted by macrophages which were ...
• Frequency of aspirin non responsiveness in patients of ischemic heart disease 

  Rizvi, Syed Khizar Abbas; Mohsin, Shahida; Saeed, Tahir; Ahmad, Saeed (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-24)

  Aspirin is widely used as an antiplatelet agent. Many patients have been noticed with recurrence of major ischemic events in- spite of antiplatelet therapy. The objective of this study was to determine frequency of aspirin ...
• The mutagenic effects of ivermectin in germinal cells and serum protein of the mouse 

  Sweify, Karima Mohammad; Darwish, Iman Abd El Moneim; Hafez, Dalia Demerdash Abd El Monem (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-24)

  Ivermectin (IVM) is a broad-spectrum anti-parasite agent. It is extremely toxic to fish and aquatic life. Some animals showed reduction in the fertility, the number of variable fetuses and sperm count following treatment ...
• Antimicrobial potential of aqueous extract of Camellia sinensis against representative microbes 

  Ishrat Khan; Tanveer Abbas; Komal Anjum; Syed Qamar Abbas; Bibi Ibtesam Shagufta; Sayed Asmat Ali Shah; Najeeb Akhter; Syed Shams ul Hassan (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-22)

  Camellia sinensis is being used for decades for its therapeutic efficacies against physiological problems and microbial infections. This study was undertaken to investigate the antibacterial and antifungal potential of ...
• The physiological and lifespan alterations in Caenorhabditis elegans exposed to different dosages of melatonin 

  Omer Karadas; Necati Ozpinar; Elif Bilgic; Fatih Ozcelik; Sema Karada (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-21)

  Aging is a process that begins at birth and ends with death. This process is accompanied by environmental effects, which cause structural and functional changes in cells and tissues. With regards to healthy aging, melatonin ...
• Optimization of process variables for enhanced production of extracellular lipase by Pleurotus ostreatus IBL-02 in solid-state fermentation 

  Rehman, Saima; Bhatti, Haq Nawaz; Bila, Muhammad; Asgher, Muhammad (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-20)

  In the present study, Pleurotus ostreatus IBL-02, a white rot basidiomycete was exploited for lipase production in solid-state fermentation (SSF). Different agro-industrial wastes such as canola-oilseed cake, cotton-oilseed ...
• Formulation conditions on the drug loading properties of polymeric micelles 

  Zhou, Jing; Jiang, Xue-hua (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-19)

  Methyl poly(ethylene glycol) grafted poly (lactide-co-(glycolic acid)-alt-(glutamic acid) amphiphilic copolymers (PLG-g-mPEG) were fabricated polymeric micelles to load anticancer drug doxorubicin (DOX). Both blank and ...
• Protective role of Monotheca buxifolia and Bosea amherstiana against H2O2 -induced DNA damage in human lymphocytes and its effect on oxidative enzymes 

  Hassan, Said; Ahmad, Bashir; Shah, Jehandar; Bashir, Shumaila; Jahan, Sarwat; Hizbullah, Hizbullah (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-18)

  Experimental based evidence suggests that most of the medicinal plants possess a wide-ranging pharmacological and biological activity that may possibly protect tissues against O2-induced damages. The objectives of the ...
• Protective effects of vitamin D and losartan in complete Freund's adjuvant-induced arthritis in rats 

  Gaafar, Ahmed G; youssef, Amira M Abo-; Khalaf, Marwa M; saif, Ali A Abo- (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-17)

  The current study was designed to explore the protecting effects of vitamin D and losartan in treatment of rheumatoid arthritis (RA). Animals were allotted to five groups: Group I received vehicles only (vehicle control). ...
• Pumpkin (Cucurbita moschata) against Aspergillus flavus and aflatoxin B1 induced lung cyto-morphological damage in rats 

  Saddiq, Amna Ali Nasser; Awedh, Mohammad Hamza (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-15)

  The protective efficacy of pumpkin (Cucurbita moschata) fruit aqueous extract against either aflatoxin B1 (AFB1) toxicity and Aspergillus flavus fungus infection induced lung histolomorphological damage in rats ...
• Effects of aqueous leaves extract of Holoptelea integrifolia (Roxb) Planch on liver and kidney histopathology of albino rats 

  Hina Yasin; Shaukat Mahmud; Ghazala H Rizwani; Rehana Pervee; Hina Abra; Kaneez Fatima (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-14)

  Histopathological studies are an essential element to ascertain comprehensive safety profile of a drug. Unfortunately limited data are available about the toxicity of herbal remedies. Since a popular medicinal plant Holoptelea ...
• Central nervous system depressant effects of fractions of methanol leaf extract of Cissus cornifolia (Baker) Planch 

  Abdullahi Hamza Yaro; Aliyu Muhammad Mus; Jamilu Ya; Abdullahi Balarabe Nazifi; Kamaluddeen Garba (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-13)

  Cissus cornifolia is an annual herb used in the treatment of mental derangement in the African Traditional Medicine. As part of a continuous research on this medicinal plant to scientifically validate its use in ...
• Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's dementia 

  Ikram, Huma; Haleem, Darakhshan Jabeen (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-12)

  Present study was designed to monitor the cognitive profile of the animals upon repeated administration of reserpine, so as to determine that whether these animals should be used as animal models of Parkinson’s dementia. ...

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