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Browsing Issue 2 by Title

Browsing Issue 2 by Title

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  • Anti-nociceptive potential of lyophilized Beta vulgaris L. (Beet root) powder 
    Sarfaraz, Sana; Ikram, Rahila (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-08)
    Pain is a very common symptom and pain management is most important challenge to alleviate the suffering and for improving the quality of life of those living with chronic pain. Beet root is a vegetable consumed as salad ...
  • Antidiabetic and antidyslipidemic potential of Echinops echinatus in rat models of type I and type II diabetes 
    Chaudhry, Shafqat Rasul; Akram, Adnan; Aslam, Naveed; Wajid, Muhammad; Iqbal, Zafar; Nazir, Imran; Jabeen, Qaiser; Muhammad, Sajjad (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-05)
    Echinops echinatus is traditionally an important plant that finds its extensive use as a diuretic, antiinflammatory, anti-pyretic, nerve tonic, abortifacient, aphrodisiac, antiasthmatic, and antidiabetic agent. The current ...
  • Antimicrobial potential of aqueous extract of Camellia sinensis against representative microbes 
    Ishrat Khan; Tanveer Abbas; Komal Anjum; Syed Qamar Abbas; Bibi Ibtesam Shagufta; Sayed Asmat Ali Shah; Najeeb Akhter; Syed Shams ul Hassan (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-22)
    Camellia sinensis is being used for decades for its therapeutic efficacies against physiological problems and microbial infections. This study was undertaken to investigate the antibacterial and antifungal potential of ...
  • Antioxidant and antimicrobial activities of various extracts from Engleromyces sinensis fruiting body 
    Wang, Fei; Zhou, Xiao; Shen, Xiao-Ye; Hou, Cheng-Lin (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-04-03)
    Engleromyces sinensis, as rare macro-ascomycetes and traditional ethnomedicine in the southeast part of China, have been applied in anti-infection, anti-inflammatory and anti-tumor for a long time. In this study, ...
  • Central nervous system depressant effects of fractions of methanol leaf extract of Cissus cornifolia (Baker) Planch 
    Abdullahi Hamza Yaro; Aliyu Muhammad Mus; Jamilu Ya; Abdullahi Balarabe Nazifi; Kamaluddeen Garba (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-13)
    Cissus cornifolia is an annual herb used in the treatment of mental derangement in the African Traditional Medicine. As part of a continuous research on this medicinal plant to scientifically validate its use in ...
  • Community onset of CTX-M extended spectrum β-lactamases among uropathogenic E. coli and K. pneumoniae from Karachi, Pakistan 
    Fatima, Sakina; Muhammad, Iyad Naeem; Khan, Muhammad Naseem; Jamil, Subia; Siddiqui, Tuba; Khatoon, Humera (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-10)
    Urinary tract infections (UTIs) are major health issue in developing countries like Pakistan, become more complicated with extended spectrum β-lactamase (ESBL) expression in Escherichia coli and Klebsiella pneumoniae. The ...
  • Effects of aqueous leaves extract of Holoptelea integrifolia (Roxb) Planch on liver and kidney histopathology of albino rats 
    Hina Yasin; Shaukat Mahmud; Ghazala H Rizwani; Rehana Pervee; Hina Abra; Kaneez Fatima (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-14)
    Histopathological studies are an essential element to ascertain comprehensive safety profile of a drug. Unfortunately limited data are available about the toxicity of herbal remedies. Since a popular medicinal plant Holoptelea ...
  • Effects of boric acid-linked ampicillin on the rat intra-abdominal sepsis model 
    Idiz, Ufuk Oguz; Aysan, Erhan; Firat, Deniz; Ercan, Cilem; Demirci, Selami; Sahin, Fikrettin (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-01)
    The aim of this study was to determine efficiency of a new molecule that was obtained by linking boric acid with ampicillin in treating intra-abdominal infection.Following intraperitoneal E. coli injection totwenty-one ...
  • Evaluation of anticonvulsant and antiepileptogenic activity of Euphorbia nivulia in PTZ-induced kindling model of epilepsy in mice 
    Rehman, Agha Habibur; Sharar, Shakir D Al; Ahmad, Mahmood; Akhtar, Muhammad; Khan, Younus; Ashra, Muhammad Nadeem (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-28)
    Epilepsy rema ins a major chronic neurological disorder with significantly higher refractory seizure rate. Based on the folk medicine literature, we explored the anticonvulsant and antiepileptogenic activity of aqueous ...
  • Formulation conditions on the drug loading properties of polymeric micelles 
    Zhou, Jing; Jiang, Xue-hua (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-19)
    Methyl poly(ethylene glycol) grafted poly (lactide-co-(glycolic acid)-alt-(glutamic acid) amphiphilic copolymers (PLG-g-mPEG) were fabricated polymeric micelles to load anticancer drug doxorubicin (DOX). Both blank and ...
  • Frequency of aspirin non responsiveness in patients of ischemic heart disease 
    Rizvi, Syed Khizar Abbas; Mohsin, Shahida; Saeed, Tahir; Ahmad, Saeed (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-24)
    Aspirin is widely used as an antiplatelet agent. Many patients have been noticed with recurrence of major ischemic events in- spite of antiplatelet therapy. The objective of this study was to determine frequency of aspirin ...
  • Hepato-protective effect of Allium sativum against immobilization stress in rats 
    Syed Kashif Zaidi; Shakeel Ahmed Ansari; Shams Tabrez; Ghulam Md. Ashraf; Shazi Shakil; Mohammad Alam Jafri; Muhammad Imran Naseer; Wesam H Abdulaal; Naheed Banu; Muhammed Al-Qahtani (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-07)
    The purpose of the current study was to examine immobilization stress-induced antioxidant defense changes and estimation of the antioxidant potential of pre and post stress treatment of aqueous garlic extract in rat’s ...
  • In vitro antimicrobial activity and phytochemical analysis of different solvent extracted samples from medicinally important Litsea glutinosa 
    Bakht, Jehan; Farooq, Muhammad; Iqbal, Arshad (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-06)
    The present research work investigate the antimicrobial activities of crude methanolic extracted samples from the leaves of Litsea glutinosa against different microorganisms through disc diffusion assay applied in two ...
  • Leptin as a predictor of anthropometric cutoff points for obesity 
    Hingorjo, Mozaffer Rahim; Nadeem, Shazia; Qureshi, Masood Anwar; Zehra, Sitwat (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-02)
    This study was conducted to find the association between leptin and adiposity indices. Secondly, to identify optimal threshold of various anthropometric indices for obesity, as assessed by 75th percentile of leptin levels, ...
  • Metabolomics and marker-based stability studies of methanol extract of seeds of Syzygium cumini L 
    Islam, Muhammad; Shehzad, Naureen; Salman, Muhammad; Zahi, Fakhra; Qamar, Shaista; Danish, Muhammad Z; Saeed, Hamid; Hashmi, Furqan K; Khan, Humaira M; Khan, Muhammad T; Bukhar, Nadeem I; Hussain, Khalid (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-04)
    Though, herbal medicines are prone to deterioration upon storage due to their complex nature, but less attention has been paid to investigating stability of such products to assign shelf-life. Therefore, the present study ...
  • MINI REVIEW Wound healing potential of edible plants 
    Katyakyini Muniandy; Sivapragasam Gothai; Palanisamy Arulselvan; Subbiah Suresh Kumar; Mohd Esa Norhaizan; Arthanari Umamaheswari; Sharida Fakurazi (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-04-01)
    Wound healing is a natural intricate cascade process involving cellular, biochemical and molecular mechanism to restore the injured or wounded tissue. Malaysia's multi-ethnic social fabric is reflected in its different ...
  • The mutagenic effects of ivermectin in germinal cells and serum protein of the mouse 
    Sweify, Karima Mohammad; Darwish, Iman Abd El Moneim; Hafez, Dalia Demerdash Abd El Monem (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-24)
    Ivermectin (IVM) is a broad-spectrum anti-parasite agent. It is extremely toxic to fish and aquatic life. Some animals showed reduction in the fertility, the number of variable fetuses and sperm count following treatment ...
  • Nifedipine-loaded polymeric nanoparticles: Preparation and in vitro characterization 
    Ozakar, Emrah; Ceti, Meltem; Ate, Orhan; Hacimuftuoglu, Ahmet (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-11)
    The purpose of the current study was to prepare nifedipine (NF) loaded-PLGA nanoparticles (NPs) using two different methods (nanoprecipitation method (N-2) and emulsion-solvent evaporation method (N-4)) to achieve the ...
  • Optimization of process variables for enhanced production of extracellular lipase by Pleurotus ostreatus IBL-02 in solid-state fermentation 
    Rehman, Saima; Bhatti, Haq Nawaz; Bila, Muhammad; Asgher, Muhammad (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-20)
    In the present study, Pleurotus ostreatus IBL-02, a white rot basidiomycete was exploited for lipase production in solid-state fermentation (SSF). Different agro-industrial wastes such as canola-oilseed cake, cotton-oilseed ...
  • The physiological and lifespan alterations in Caenorhabditis elegans exposed to different dosages of melatonin 
    Omer Karadas; Necati Ozpinar; Elif Bilgic; Fatih Ozcelik; Sema Karada (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-21)
    Aging is a process that begins at birth and ends with death. This process is accompanied by environmental effects, which cause structural and functional changes in cells and tissues. With regards to healthy aging, melatonin ...

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