• Methylphenidate increases the urinary excretion of vanillylmandelic acid in rats that is attenuated by buspirone co-administration 

  Alam, Nausheen; Ikram, Rahila; Naeem, Sadaf; Kashif, Sadia Suri; Bashir, Lubna; Naz, Shazia; Wasi, Nousheen (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  Methylphenidate is a psychostimulant used for the treatment of (ADHD) attention deficit hyperactivity syndrome in children and adults. After chronic administration it is known to produce behavioral disorders including ...
• Optimization of physicochemical parameters for maximum amylase production by indigenously isolated Bacillus cereus AS2 strain 

  Rehman, Aneela; Saeed, Asma; Asad, Wajeeha; Kiran, Tabbassum; Naz Baloch, Muneera; Eijaz, Sana (2019-03-20)

  Amylases are enzymes that catalyze the hydrolysis of starch into highly valuable products of economic significance. Amylases are used extensively in various industrial sectors. Microbial sources particularly Bacillus species ...
• In vitro Spectroscopic studies on drug interaction of cefpodoxime proxetil and H2 receptor blockers 

  Iqbal, Sadia; Hassan, Sohail; Zaheer, Erum; Ahmed, Ateka; Hussain, Kanwal; Shereen; Furqan, Hina (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  One of the relatively advance 3rd generation cephalosporins, cefpodoxime proxetil, is being used all-around. Generally, these are used for the cure of infections allied to urinary and respiratory tract. These cephalosporins ...
• Vitamin D and bone metabolism in breast cancer patients in Karachi, Pakistan 

  Udani, Shamsa Kanwal; Akhtar Qureshi, Shamim; Lateef, Tooba; Jafri, Lena; Naeem Effendi, Muhammad Umer; Raheem, Ahmed; Bilal Azmi, Muhammad; Rais, Sumera; Jahan, Musarrat; Akram Mudassir, Hina; Akram, Bushra; Alvi, Muhammad; Khan, Shaista; Ghani, Farooq (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  Breast cancer is one of the common types of malignancy worldwide and in Pakistan. The heterogeneous disease itself and its complex treatment leads to various bone-affecting complications that make breast cancer patients ...
• Metabolite profiling of Cycas revoluta leaf extract and docking studies on alpha-glucosidase inhibitory molecular targets by phytochemicals 

  Arshad, Muhammad; Mumtaz, Muhammad Waseem; Chaudhary, Ayoub Rashid; Rashid, Umer; Ali, Mukhtar; Mukhtar, Hamid; Adnan, Ahmad; Ali Raza, Syed (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  The leaves of Cycas revoluta were explored for their antioxidant, α-glucosidase and α-amylase inhibitory properties to develop safe and diet based therapeutic treatment of diabetes. In optimized fractionation, 60% ethanol ...
• Frequency of multi drug resistant Pseudomonas aeruginosa in different wound types of hospitalized patients 

  Ijaz, Muhammad; Siddique, Abu Baker; Hidayat Rasool, Muhammad; Shafique, Muhammad (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  Pseudomonas aeruginosa colonization is one of the major complications of wound infection leading to higher risk of morbidity and mortality. The trend of antibiotic resistant against Pseudomonas aeruginosa is increasing day ...
• Correlation of metformin with intravenous iodinated contrast media and precautions 

  Shah, Muhammad Adeel; Niazi, Samia Gul; Mahmood Tahir, Imtiaz; Shahid, Ifra; Parveen, Abida; Sana, Sadia; Akhter, Naheed; Iftikhar, Naila; Ashraf, Saba; Siddique, Zafaar; Mushtaq, Yasmin; Khan, Muslim; Akram, Muhammad (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  To discuss metformin and iv-contrast induced acute renal failure with its reported cases worldwide, associated risk factors and precautions that can be taken to reduce this tragedy & to address this sensitive issue to my ...
• Development and validation of reverse phase HPLC method for determination of angiotensin receptor blocking agent irbesartan in plasma 

  Nisa, Zeb-un; Ali, Syed Imran; Rizvi, Mehwish; Ahmed Khan, Maqsood; Akhter Sultan, Rafi; Fatima, Rasheeda; Shaheen, Najma; Zafar, Farya; Kashif, Sadia Suri; Khatian, Najeeb (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  A sensitive, reproducible and modest analytical procedure was developed and validated for evaluation of irbesartan in human plasma. LLE (Liquid-Liquid extraction) of the drug was carried out with acetonitrile (1:1 v/v). ...
• Dermocosmetic emulgels for anti-aging effects: Evidence from chromatographic and non-invasive biophysical techniques 

  Kashif, Muhammad; Akhtar, Naveed (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  Persimmon Fruits (Diospyros kaki L.f, Ebenaceae) and its active principles have long been used in traditional medicines for various cosmetics and skin conditions, however clinical efficacy on various facial skin parameters ...
• Development and validation of RP-HPLC method for simultaneous determination of cefpodoxime proxetil and H2 receptor antagonists in pharmaceutical dosage forms 

  Hassan, Sohail; Iqbal, Sadia; Zaheer, Erum; Hassan, Amir; Hamid, Shaista; Ali, Mohsin; Akram, Arfa; Maroof, Syed Zohaib; Abedin, Saima; J Khan, Sidra (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  A new method on RP-HPLC is devised and validated, as per ICH guidelines, for the synchronous estimation of cefpodoxime proxetil and H2-receptor antagonits that are Cimetidine, Famotidine and Ranitidine. The method is simple, ...
• Biologically active scaffolds: Synthesis, characterization and studies of oxino bis-pyrazoles by environmental friendly method 

  Aslam, Noreen; M. White, Jonathan; Ghafoor, Abdul; Shafique, Ajmal; Hassan Nasim, Faizul; Jahan, Bakht; Ashraf, M; Jabeen, Mussarat; Madiah Zafar, Ansa; Noreen, Shazia; Sajid, Naveed; Ain Khan, Misbahul (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  In the present communication, synthesis of bis-pyrazolones containing aryl motifs (4-14) and their αglucosidase inhibitory activity, hemolytic and antihemolytic activities were reported. The newly synthesized compounds ...
• Effect of 4-amino-3-nitrobenzoic acid on the expression level of the trans-sialidase gene in Trypanosoma cruzi epimastigotes 

  Vazquez-Jimenez, Lenci K; Paz-Gonzalez, Alma D; Kashif, Muhammad; J JuarezRendon, Karina; Nogueda-Torres, Benjamín; Bocanegra-Garcia, Virgilio; Rivera, Gildardo (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  Trans-sialidase of Trypanosoma cruzi (TcTS) is a key enzyme in the infection process from parasite to host; therefore, it has been considered an important target for developing new anti-Chagas drugs. Different compounds ...
• Hepaotoprotective and nephroprotective activities of Pistacia integerrima fruit extract in paracetamol intoxicated male rabbits with effect on blood cells count 

  Ilahi, Ikram; Khan, Jahangir; Ali, Hazrat; Ghias, Mehreen; Rahim, Abdur; Ul Haq, Taqweem; Anwar Sajad, Muhammad; Zaman, Shah; Rahim, Gul; Jan, Tour; Ahmad, Saeed; Ullah, Shariat; Mehreen, Sania; Zafar, Huma (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  The beneficial effects of Pistacia integerrima (PI) fruit methanol extract on some liver and kidney related parameters and blood cells count of paracetamol (PCM) intoxicated male rabbits were studied. Paracetamol intoxication ...
• Neuroprotective evaluation of Tribulus terrestris L. in aluminum chloride induced Alzheimer’s disease 

  Chauhdary, Zunera; Saleem, Uzma; Ahmad, Bashir; Shah, Shahid; Shah, Muhammad Ajmal (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  Tribulus terrestris (T.T) is enriched with steroidal saponins and flavonoids which have neuroprotective effect. The study was aimed to explore the potential of T.T methanol extract (T.T ME) for anti-Alzheirmer activity ...
• Soil-transmitted helminth infections in school children of three districts of Malakand region, Khyber Pakhtunkhwa, Pakistan 

  Khan, Wali; Khan, Jahangir; Khan, Naeem; Iqbal, Ruhoollah; Ullah, Atta; Ghaffar, Rukhsana; Mehmood, Sardar Azhar; Ahmad, Shabir; Khan, Sheema; Ullah, Farman (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  Information on prevalence of soil-transmitted helminth (STH) infections among school children is scarce in Pakistan. This study was aimed to investigate the prevalence of soil-transmitted helminth in school children of ...
• Stability and in vitro release kinetic studies of cinitapride (1mg) mouth dissolving tablets 

  Bushra, Rabia; Ghayas, Sana; Ali, Huma; Zafar, Farya; Shafiq, Yousra; Ahmed, Kamran (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  Cinitapride has been widely given in gastro-esophageal reflux disease (GERD) and dysphagia due to irregularities of GI motilities. Mouth dissolving tablets were prepared for rapid availability and action of drug. Multipoint ...
• Supplementation of Cannabis sativa L. leaf powder accelerates functional recovery and ameliorates haemoglobin level following an induced injury to sciatic nerve in mouse model 

  Aziz, Nimra; Rasul, Azhar; Ahmad Malik, Shoaib; Anwar, Haseeb; Imran, Ali; Razzaq, Aroona; Shaukat, Arslan; Shahid Kamran, Syed Kashif; Gonzalez de Aguilar, Jose-Luis; Sun, Tao; Hussain, Ghulam (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  Peripheral nerve injury is a common condition with a multitude of signs and symptoms. The major consequence of injury is limited physical activity. Presently, we are lacking effective therapies for PNI and it is need of ...
• Immune modulatory and anti-oxidative effect of selenium against pulmonary tuberculosis 

  Imran Hussain, Muhammad; Ahmed, Waqas; Nasir, Muhammad; Hassan Mushtaq, Muhammad; Sheikh, Ali Ahmad; Yousaf Shaheen, Arfat; Ali, Shahbaz; Iqbal, Sanaullah (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  Prevalence of pulmonary tuberculosis (TB) in Pakistan is due to poor living conditions, malnutrition and low immunity. The present project was conducted to show the role of selenium complement to enhance the immune status ...
• Occurrence of ESBL-producing Klebsiella pneumoniae in hospital settings and waste 

  Chaudhry, Tamoor Hamid; Aslam, Bilal; Imran Arshad, Muhammad; Nawaz, Zeeshan; Waseem, Muhammad (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  Presence of multiple drug resistant pathogens in hospital waste is a serious public health concern, because it may ultimately be disseminated to the human. Current study was designed with the objective to estimate the ...
• Quality of life before and after total knee arthroplasty in clinical settings across Lahore, Pakistan 

  Shah, Atzaz Moin Ul Din; Afzal, Farjad; Ans, Muhammad; Ayaz, Sultan; Niazi, Samia Gul; Asim, Muhammad; Imtiaz Mahmood, Tahir; Akram, Muhammad (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)

  Knee osteoarthritis is a common disabling condition that affects a larger number of populations aged above 40 years and this habitually required knee arthroplasty to reinstate leg function, to improve the pain as well as ...

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