• Study of Vitamin D deficiency and contributing factors in the population of Hyderabad, Pakistan 

  Kandhro, Farhatullah; Dahot, Muhammed Umar; Naqvi, Syed Habib Ahmed; Ujjan, Ikram Uddin (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-25)

  The study of vitamin D (25-OHD) deficiency was intended to analyse the incidence and some contributing factors amid healthy individuals of different living standards in general population of Hyderabad and its adjacent ...
• HPLC-UV method for simultaneous determination of sparfloxacin and dexamethasone sodium phosphate in eye drops 

  Prakash, Katakam; Sireesha, Karanam R (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-24)

  A simple, sensitive liquid chromatographic method was developed and validated for the simultaneous estimation of sparfloxacin and dexamethasone sodium phosphate in bulk and pharmaceutical formulations. Optimum separation ...
• Understanding impact of pre-dissolved polymers on dissolution behavior of soluble carbamazepine cocrystal 

  Ullah, Majeed; Khan, Saeed Ahmad; Shah, Syed Majid; Rabbani, Imran; Sadozai, Sajid Khan; Abbas, Naseer; Bin Asad, Muhammad Hasham Hassan; Badshah, Munair; Hasan, Syed Mohammad Farid; Hussain, Izhar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-23)

  Cocrystallization is a novel approach for tackling the lower solubility concerns when they can yield solution concentration a lot better than their corresponding parent drug in crystalline form. To get the actual solubility ...
• Testicular toxicity of orally administrated bisphenol A in rats and protective role of taurine and curcumin 

  Kalender, Suna; Apaydin, Fatma Gokce; Kalender, Yusuf (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-22)

  Bisphenol A (BPA) is an endocrine disrupting chemical widely used in the world. Curcumin, the yellow bioactive compound of turmeric has demonstrated its antioxidant activities. Taurine is a low-molecular weight organic ...
• Hepatoprotective effect of ketoconazole in chronic liver injury model 

  Akhtar, Usman; Ahmed, Mobasher; Tayyeb, Asima; Shehzad, Umara; Ali, Gibran (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-21)

  Ketoconazole is a first orally available anti-fungal drug which has been reported as a potent inhibitor of human cytochrome P-450. The present study was designed to examine the heptoprotective effect of ketoconazole in ...
• Synthesis and antimicrobial screening of some 1, 3, 4-oxadiazoles and their molecular properties prediction through ‘rule of five’ 

  Upadhyay, Prabhat K; Mishra, Pradeep (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-20)

  : In the current study, a series of 5-(4-substituted phenyl) - 1, 3, 4-oxadiazole-2-thiols (4a-h) were prepared from 4-substituted benzoic acid hydrazides (3a-h). The chemical structures of synthesized compounds were ...
• Evaluation of gender difference in pharmacokinetics of Candesartan cilexetil in the fasted state by RP-HPLC: A single dose comparative study 

  Nawaz, Hafiz Awais; Masood, Muhammad Irfan; Abbas, Mateen; Usman, Muhammad; Khan, Abdul Muqeet; Rasheed, Huma; Riffat, Sualeha (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-19)

  To compare the pharmacokinetics of candesartan cilexetil in healthy male and female volunteers in order to identify possible influence of gender and to improve therapeutic outcomes, an HPLC method for the quantification ...
• Studies on the anti-fatigue activities of Irpex lacteus polysaccharideenriched extract in mouse model 

  Wang, Juan; Li, Chenliang; Hu, Wenji; Li, Lanzhou; Cai, Guangsheng; Liu, v; Wang, Di (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-18)

  Irpex lacteus is a white rot basidiomycete proposed for a wide spectrum of biotechnological applications. However, few studies examined its effects on exercise performance and physical fatigue. The present study evaluated ...
• Salvia hispanica (White chia): A new window for its antidepressant and memory boosting activity 

  Adel, Abeer; Ikram, Rahila; Wasi, Nousheen (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-17)

  To determine the effects of Salvia hispanica on activities related to memory, anxiety and depression. Albino rats as well as albino mice were utilized in the current study. Two groups of animals were made including 10 ...
• Anticonvulsive activity of duloxetine: A new choice for the epileptic patients with depression. 

  Wu, Yi; Huang, Yuping; Song, Mingxia; Zhang, Zongping; Liang, Zhen; Deng, Xianqing (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-16)

  The aim of this study was to investigate the antiepileptic effects of duloxetine in the maximal electroshock test and convulsions induced by four compounds: Pentylenetetrazole, 3-mercaptopropionic acid, thiosemicarbazide, ...
• Synthesis, spectral analysis and biological evaluation of sulfamoyl and 1,3,4-oxadiazole derivatives of 3-pipecoline 

  Rehman, Aziz-ur; Aslam, Saira Jabeen; Abbasi, Muhammad Athar; Siddiqui, Sabahat Zahra; Rasool, Shahid; Shah, Syed Adnan Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-15)

  Heterocyclic chemistry is an important field of organic chemistry due to therapeutic potential. The minor modification in the structure of poly-functional compounds has great effect on therapeutic ability. In the presented ...
• Polymorphic properties and dissolution profile of efavirenz due to solvents recrystallization 

  Wardhana, Yoga Windhu; Soewandhi, Sundani N; Wikarsa, Saleh; Suendo, Veinardi (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-14)

  Polymorphism occurs in pharmaceutical compounds affect to the physicochemical quality and goal of therapy. Thus, quality evaluation of different crystal forms should be assessed especially the solubility and dissolution ...
• Comparative liver function assessment of natural and available drug (Ferrous sulfate) for iron-deficiency anemia in rat model 

  Baqa, Kulsoom; Waris, Nazish; Butt, Anum; Nazim, Urooj; Abbasi, Sumera Rais; Naz, Afshan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-13)

  To assess the comparative effect of anti-anaemic drug (ferrous sulfate) with naturally occurring anti-anaemic compound (Illicium verum commonly called star anise) on liver in rat model. Model and both test groups were ...
• Antagonistic activity of an epibiotic Bacillus strain SG3 from Gorgonian coral, Junceella juncea (Pallas, 1766) 

  Thangapaul, Alex John; Praveevn, M Mark; Chinnachamy, Chellaram (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-12)

  Marine environment continues to be a huge source of pharmacologically active compounds that cure deadly disease. This research investigates the bioactive efficacy of bacteria isolated from surface of the coral, Junceella ...
• Structural investigation of some novel synthesized Schiff base Transition metal complexes derived from drug together with Antimicrobial study 

  Mumtaz, Amina; Mahmud, Tariq (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-11)

  A new series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes with a novel Schiff base were synthesized by the condensation of sulphadizine and thiophene-2-carbaldehyde.The ligand ...
• A novel realgar-indigo naturalis formula more effectively induces apoptosis in NB4 cells 

  Xie, Qinjian; Yu, Lan; Wang, Xin; Wu, Zhengrong; Zhi, Dejuan; Yang, Jing; Guo, hiwang; Wu, Tao; Sun, Yin; Zhao, Longhe; Ding, XiaoYu; Khan, Akbar; Li, Hongyu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-10)

  Realgar as a kind of arsenic agent is currently used to treat APL in China. The effectiveness and low toxicity of realgar have been verified, lower than arsenic trioxide. Although the therapeutic efficacy of realgar is ...
• Comparison of intra articular NSAID (ketorolac) injection versus hyaluronic acid injection for the mean decrease of pain score (according to UCLA shoulder rating scale) in the management of adhesive capsulitis 

  Akhtar, Muhammad; Nadeem, Rana Dil Awaiz; Gillani, Syed Faraz Ul Hassan Shah; Cheema, Omer Iqbal; Nadeem, Mohammed Rajaab (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-09)

  Adhesive capsulitis is painful condition, associated with gradual loss of active and passive shoulder motion that has a disabling capability. In this study we compared the short term outcome by measuring the mean decrease ...
• Antimicrobial screening of some selected Turkish medicinal plants 

  Moghaddam, Naznoosh Shomali; Eryılmaz, Mujde; Altanlar, Nurten; Yıldırım, Ozlem (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-08)

  For many years, plants are used for treatment of various diseases. In general, plants have rather more therapeutic benefits and fewer adverse effects compared with the synthetic drugs. The purpose of this study was to ...
• Molecular signatures of Calpain 10 isoforms sequences, envisage functional similarity and therapeutic potential 

  Chaudhry, Bushra; Hanif, Farina; Saboohi, Kausar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-07)

  Calpain 10 plays a role in insulin secretion, action and susceptibility to type 2 diabetes. The mechanism through which it influences the insulin secretion and action is not completely defined. A structural bioinformati ...
• Pharmacological analysis of hydroethanolic extract of Senna alata (L.) for in vitro free radical scavenging and cytotoxic activities against HepG2 cancer cell line 

  Sugumar, Mohanasundaram; Doss, Victor Arokia; Maddisetty, Prasad; Rangaraju, Magesh; Kandhasamy, Sivakumar; Munuswamy, Subathra (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-05-06)

  The main objective of this study was to evaluate the hydroethanolic extract of Senna alata for the possible free radical scavenging and cytotoxic properties. Using such hydroethanolic extract, various in vitro antioxidant ...

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