• Molecular analysis of PmrA and PmrB genes in colistin-resistant Pseudomonas aeruginosa strains via PCR method 

  Heidari, Leila; Sepahvand, Shahriar; Darvishi, Mohammad; Jafari, Reyhaneh (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-07)

  Pseudomonas aeruginosa is one of the most common pathogens in hospitals. Along with the advent of various drug resistance patterns, rising resistance to colistin, the last alternative against this bacterium, is reported ...
• In vitro and in vivo anti-arthritic evaluation of Polystichum braunii to validate its folkloric claim 

  Saleem, Ammara; Saleem, Mohammad; Akhtar, Muhammad Furqan; Sharif, Ali; Javaid, Zeeshan; Sohai, Kashif (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-06)

  Medicinal plants are playing an imperative role in the therapy for treating various chronic ailments including arthritis. The present study was focused on finding in vitro and in vivo anti-arthritic potential of P. braunii ...
• Antifungal activity of silver nanoparticles from Aspergillus niger 

  Hassan, Shafaq Aiyaz; Hanif, Erum; Khan, Umme Hani; Tanoli, Asad Khan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-05)

  In recent years, silver nanoparticles have gained attention because of their high surface area to volume ratio that makes them more advantageous than their bulky counterparts. Apart of chemical and physical methods of ...
• Synthesis and in vitro cholinesterase inhibitory potential of dihydropyridine derivatives 

  Zafar, Ansa Madeeha; Ashraf, Muhammad; Aslam, Samina; Naureen, Sadia; Aslam, Noreen; Jabeen, Mussarat; Sajid, Naveed; Ghafoor, Abdul; Noreen, Shazia; Shahi, Mahrzadi Noureen; Khan, Misbahul Ain; Iqbal, Ambar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-04)

  Twelve derivatives of dihydropyridine derivatives (6-17) were synthesized and evaluated for in-vitro cholinesterases (AChE, BChE) inhibitory activity. All compounds showed potent activity with IC50 values between 0.21±0.003 ...
• Computational screening of phytochemicals against survivin protein: A potent target for cancer 

  Hussain, Ghulam; Ashfaq, Usman Ali; Rahman, Mahmood-ur; Masoud, Muhammad Shareef; Nahid, Nazia; Bhinder, Munir Ahmad; Aslam, Nosheen; Yousaf, Numan; Ahmed, Uzair; Qasim, Muhammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-04)

  Survivin (IAP proteins) is considered as a significant target for anticancer drug research owing to its upregulation in tumor cells to mediate resistance to apoptotic stimulus. The current study aimed to investigate ph ...
• High molecular weight cross linked chitosan nanoparticles for controlled release of 5-Fluorouracil; Enhances its bioavailability 

  Sethi, Aisha; Ahmad, Mahmood; Khan, Waheed S (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-02)

  The aim of study was cross linking of high molecular weight chitosan nanoparticles containing 5-fluorouracil to improve dissolution rate and ultimately enhance its bioavailability by reverse emulsion/micelles method and ...
• An assessment of bioavailability of acrylate based pH-sensitive complexes of lovastatin 

  Mehmood, Hafiz Qasim; Faran, Syed Ali; Chaudhry, Mueen Ahmad; Khalid, Syed Haroon; Khan, Ikram Ullah; Hassan, Waseem; Ashfaq, Rabia; Asghar, Sajid (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-01)

  Lovastatin (LSN), a potent anti-hyperlipidemic drug, possesses poor bioavailability due to its very low aqueous solubility. The objective of this study was to establish a relationship between increased drug solubility ...
• Evaluation of pharmacological and toxic effects of ethanolic extract of radish pods in albino rabbits: A biochemical and histopathological study 

  Younus, Ishrat; Siddiq, Afshan; Baig, Sadia Ghousia; Khan, Saira Saeed; Ahmed, Shadab; Osama, Muhammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-21)

  Radish pods are known as vegetable eaten as a part of diet. Though the pharmacologic potential of radish has been well known but there are fewer reports regarding pharmacological and toxic effects of radish pods. On account ...
• Pharmacokinetics profile of serum and cellular Sofosbuvir along with its concentration effect analysis in HCV patients receiving Sofosbuvir and Ribavirin 

  Ahmed, Bilal; Munir, Bushra; Ghaffar, Abdul; Yameen, Muhammad; Jalal, Fatima; Farooq, Muhammad Umar; Shehzadi, Saba; Ashraf, Sara; Liaqat, Ayesha (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-20)

  Sofosbuvir along with ribavirin is being widely used for treatment of HCV in Pakistan but it may show delayed response and reoccurrence of disease in some cases. The aim of the study was to investigate pharmacokinetics ...
• Persistence and safety assessment of novel probiotic strain Lactobacillus plantarum 1 strain Lp86 and Lp36 in Salmonella typhi infected mice 

  Baloch, Muneera Naz; Zafar, Urooj; Haider, Fouzia; Mojgani, Naheed; Eijaz, Sana; Siddiqui, Roquya (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-19)

  The species of Lactic acid bacteria are known to confer beneficial effects on the host by inhabiting in their gastrointestinal tract (GIT). They succeed in surviving the harsh conditions of the GIT by exhibiting strong ...
• Synthesis, lipoxygenase inhibition activity and molecular docking of oxamide derivative 

  Rehman, Saba Fazal-ur; Wasim, Agha Arslan; Iqbal, Sadaf; Khan, Maria Aqeel; Lateef, Mehreen; Iqbal, Lubna (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-18)

  In this study, a range of oxamide ligands were synthesized by the reaction of amines with oxalyl chloride in basic medium. Spectroscopic and analytical techniques such as IR, 1H-NMR and ESI-MS techniques were used for ...
• Formulation optimization, in vitro characterization and stability studies of sustain release tablets of Ketoprofen 

  Hafeez, Abdul; Razvi, Nighat; Talib, Nasira; Ghayas, Sana; Anjum, Fakhsheena; Bushra, Rabia (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-17)

  The aim of the current study was to formulate sustain release (SR) tablets of ketoprofen. Five batches (batch I -V) of matrix based ketoprofen tablet were prepared by dry granulation method using hydroxyl propyl methyl ...
• Proximate analysis and in vitro biological assays of Saussurea hypoleuca Spreng. root 

  Arshad, Numera; Ishtiaq, Saiqa (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-16)

  Considering the growing interest in medicinal plants having imperative phytoconstituents, a research has been steered to standardize the crude drug from “Saussurea hypoleuca root” by assessing its primary, secondary ...
• Assessment of antiviral and antibiotic combination treatment in influenza-A H1N1 induced acute kidney injury among hospitalized patients 

  Ishaqui, Azfar Athar; Sulaiman, Syed Azhar Syed; Alsultan, Mohammed Taher; Khan, Irfanullah; Nami, Hamad Al (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-15)

  The aim of the study is to assess and compare the impact of antiviral drug alone and in combination with antibiotic for prevention of Influenza-A H1N1 induced acute kidney injury (AKI) in hospitalized patients. Hospitalized ...
• Evaluation of antibiotic resistance pattern in clinical isolates of Staphylococcus aureus 

  Hanif, Erum; Hassan, Shafaq Aiyaz (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-14)

  Staphylococcus aureus is a common skin colonizer as well as opportunistic pathogen causing serious diseases including bacteremia, endocarditis and a number of different infections. It has a unique ability to swiftly respond ...
• Molecular identification of blaCTX-M and blaTEM genes among multidrug resistant Enteropathogenic Escherichia coli isolated from children 

  Nawaz, Zeeshan; Zahoor, Muhammad Kashif; Siddique, Abu Baker; Aslam, Bilal; Muzammil, Saima; Yasmin, Aysha; Fayyaz, Iqra; Zahoor, Muhammad Asif (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-13)

  : In this cross sectional study (June 2016 to June 2017), we studied the isolation and molecular characterization of multi-drug resistant Escherichia coli (MDR-E. coli) from children suffering from diarrhea. For this ...
• Ligand based screening of chemical constituents from African medicinal plants for the identification of MAOB inhibitors 

  Fatima, Rida; Naim, Asma; Naeem, Sadaf (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-12)

  Ligand based virtual screening (LBVS) is based on the hypothesis that similar structures have similar biological functions. In this research paper, ligand based virtual screening has been performed in order to predict the ...
• Synthesis, characterization, antimicrobial and enzyme inhibitory studies of moxifloxacin with aromatic carboxylic acids 

  Akhtar, Mahwish; Sultana, Najma; Arayne, Mohammad Saeed; Siddiqi, Tanveer Ahmed; Khan, Ajmal (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-11)

  A series of carboxamide derivatives of moxifloxacin has been synthesized. The synthesized derivatives has been characterization by using spectroscopic techniques such as UV-Vis, IR, H1NMR and Mass spectra, which suggested ...
• In vivo study to compare the effects of choline with fluoxetine and clozapine for the modulation of cognitive behavior (Learning memory and exploratory behavior) 

  Ahsan, Mohammad Iqbal; Khan, Rafeeq Alam; Masood, Syed Mohammad; Jaffery, Aeliya; Jaffery, Farhat Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-10)

  Cognitive behavior is associated with physiological processes that affect the working performance of an individual. Cognitive control is used to override self-serving impulses and behave in socially desirable manner. The ...
• Non-albicans Candida species: Emergence of neglected pathogens among population of Karachi 

  Jabeen, Gul; Naz, Sehar Afshan; Jabeen, Nusrat; Shafique, Maryam; Sharafat, Shaheen; Baig, Samina; Nazeer, Sadia (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-05-09)

  Candida albicans was considered as the principal cause of opportunistic candidiasis but nowadays, neglected non-albicans Candida (NAC) species are evolving as more virulent and drug resistant strains. This research was ...

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