• Polymorphism of Interleukin-10 (IL-10, -1082 G/A) and Interleukin28B (IL-28B, C/T) in pediatric Acute Lymphoblastic Leukemia (ALL) 

  Ghufran, Hafiz; Riaz, Sehar; Mahmood, Nasir; Yaqoob, Muhammad; Shahid, Saman; Bhinder, Munir Ahmad; Anwar, Saadia; Faizan, Mahwish (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-21)

  We conducted genotypic analyses of interleukin-10 (IL-10) (-1082 G/A; GG, GA, AA) and interleukin-28B (CC, CT, TT) genes polymorphisms in acute lymphoblastic leukemia (ALL) pediatric patients in descriptive study to ...
• Pharmacological basis for the medicinal use of Alcea rosea in airways disorders and chemical characterization of its fixed oils through GCMS 

  Hanif, Muhammad; Mehmood, Malik Hassan; Ishrat, Ghazala; Virji, Safna Naozer; Malik, Abdul; Ahmed, Mansoor; Gilani, Anwarul-Hassan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-20)

  Alcea rosea L. also known as Althea rosea belongs to the Malvaceae family. This medicinal herb, traditionally used to treat several conditions including airway disorders like asthma and chronic bronchitis. This study ...
• Influence of Peganum harmala peptides on the transcriptional activity of biofilm related genes in sensitive and resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus 

  Mirza, Rabia; Azeem, Muhammed; Qaisar, Uzma (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-19)

  Microbial biofilms have gathered interest in recent years as they have become the major cause of nosocomial infections. The abuse and misuse of antibiotics have created a selective pressure that results in widespread ...
• Ex-vivo abortifacient activity of Androsace foliosa n-hexane leaves extract on isolated rabbit uterus 

  Zaheer, Jawad; Saqib, Qazi Najam-Us-; Hashmi, Asif Mehmmod; Mukhtiar, Muhammad; Zafar, Sadia; Riaz, Muhammad; Rasool, Ghulam; Akram, Muhammad; Shah, Syed Muhammad Ali; Rahat, Saher; Khan, Faid Said (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-18)

  Androsace foliosa is a medicinal herb utilized in different areas of Pakistan for abortifacient, diabetic and liver complications. In the current research, the possible action of the n-hexane leaves extract of the Androsace ...
• Nootropic effects of synthetic flavonoid derivatives on scopolamine induced memory impairment in mice via cholinesterase inhibition and antioxidant system 

  Ghias, Mehreen; Shoaib, Mohammad; Shah, Syed Wadood Ali; Umar, Muhammad Naveed; Ullah, Shakir; Ali, Niaz; Shah, Ismail; Shafiullah, Shafiullah (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-17)

  The synthesized flavonoid derivatives (flavonols and flavones) were subjected for in-vitro anticholinesterase evaluation followed by assessment of in-vivo memory enhancing effects using animal models. The ex-vivo analysis ...
• A new approach to design 3(3-sulfamoylbenzamido) benzoic acid containing transition metal complexes: Characterization and Biological activities 

  Kamal, Shagufta; Akhter, Naheed; Noreen, Razia; Salman, Mahwish; Khan, Samreen Gul; Roheen, Taleeha; Yaqoob, Nazia; Kamal, Amna; Siddique, Waseeq Ahmed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-16)

  Zn, Cu, Co and Ni are biocompatible metals as they are active center of many enzymes in the human body. Incorporation of these biocompatible metals into 3-(o-Sulfamoylphenyl) carbamoylbenzoic acid (I) makes them able to ...
• Neurotoxic effects of titanium dioxide nanoparticles on the brain of male sprague dawley rats 

  Latif, Muhammad Asif; Jabeen, Farhat; Ali, Muhammad; Rasul, Azhar; Naz, Shahbana; Akram, Muhammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-15)

  Titanium dioxide nanoparticles have diverse applications in many fields and are used in cosmetics, sterilization, paints, tooth paste, food products, air cleaning, sunscreens and waste water treatment plants due to their ...
• Evaluation of different Pakistani medicinal plants for inhibitory potential against Echis carinatus induced Phospholipase A2 toxicity 

  Fatima, Syeda; Javed, Tariq; Khalid, Sofia; Shaheen, Nusrat; Aslam, Nazia; Latif, Muhammad; Siddique, Faheem Ahmad; Bibi, Sumbal; Mohsin, Sabeeh; Yameen, Muhammad Arafat; Ali Abid, Syed Mubasher; Khan, Shujaat Ali; Najam, Amina; Bin Asad, Muhammad Hassham Hassan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-09)

  Medicinal plants of Pakistan are known for their curative properties against snake bite as rural people have been using natural herbs for such injuries for hundreds to thousands of years. People of rural areas of Pakistan ...
• Synthesis of N,O-Carboxymethyated chitosan and its application in the development of acyclovir loaded nanoparticles 

  Adnan, Sherjeel; Ranjha, Nazar Muhammad; Hanif, Muhammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-08)

  Objective of the study was to perform a physico-chemical modification of low molecular weight chitosan (CTS) followed by its use in the formulation of nanoparticles carrier of Acyclovir (ACY). Modified polymer was used ...
• Effect of low melting hydrophilic carriers on the solubility and dissolution rate of Piroxicam using solid dispersion technique 

  Hussain, Amjad; Farrukh, Maryam; Abbas, Nasir; Irfan, Muhammad; Arshad, Muhammad Sohail; Bukhari, Nadeem Irfan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-07)

  The present study was aimed to enhance the solubility and dissolution rate of Piroxicam, a poorly water soluble drug from BCS class II. Solid dispersions (SDs) of Piroxicam Solutol and Gelucire were prepared by applying ...
• Hepatoprotective and antidiabetic effect of Guaiacum officinale in diabetes induced male albino wistar rats 

  Ibrahim, Sadaf; Naqvi, SNH; Perveen, Rehana; Abrar, Hina; Akram, Zuneera; Tabassum, Hina; Sheikh, Samina (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-06)

  The aim of present study is to evaluate the antidiabetic and hepatoprotective effect of Guaiacum officinale in streptozotocin induced male albino rats. The methanolic bark extract of Guaiacum officinale was administered ...
• Purification and modification of Cordia myxa gum to enhance its nutraceutical attribute as binding agent 

  Tahir, Muhammad Farrukh; Bukhari, Shazia Anwer; Anjum, Fozia; Qasim, Muhammad; Anwar, Haseeb; Naqvi, Syed Ali Raza (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-05)

  The aim of the present study was to purify, hydrolyze and modify the Cordia myxa gum to document its binder potential in pharmaceutical tablets formulation. The hydrolysis and modification was carried out to remove ...
• Hispolon induces apoptosis against prostate DU145 cancer cells via modulation of mitochondrial and STAT3 pathways 

  Masood, Muqaddas; Rasul, Azhar; Sarfraz, Iqra; Liu, Sitong; Liu, Xintong; Wei, Wei; Li, Jiang; Li, Xiaomeng (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-04)

  Hispolon, a bioactive polyphenolic entity extracted from Phellinus linteus, possesses anticancer, antiinflammatory and anti-oxidant properties. Despite the reported therapeutic effects of this natural chemical entity, ...
• Reconnoitring the impact of different extraction techniques on ginger bioactive moieties extraction, antioxidant characterization and physicochemical properties for their therapeutic effect 

  Rehman, Tanzeel-ur; Arshad, Muhammad Umair; Ahmad, Rabia Shabir; Rasool, Bilal; Hussain, Ghulam; Saeed, Farhan; Shahbaz, Muhammad; Ahmed, Aftab; Imran, Muhammad; Khan, Muhammad Asif; Faiz, Furukh; Bano, asmin; Munir, Rizwan; Nadeem, Muhammad; Jabeen, Farhat; Imran, Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-03)

  The core directive of current study was to compare the different extraction techniques for their extraction yield of ginger bioactive moieties. Purposely, ultrasonic assisted and supercritical fluid extraction techniques ...
• Design, synthesis, in-silico study and anticancer potential of novel n-4- piperazinyl-ciprofloxacin-aniline hybrids 

  Akhtar, Rabia; Zahoor, Ameer Fawad; Rasul, Azhar; Ahmad, Matloob; Anjum, Muhammad Naveed; Ajmal, Muhammad; Raza, Zohaib (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-02)

  Synthesis and characterization of novel structural hybrids of ciprofloxacin linked with a variety of anilides have been described in this paper. Antitumor activity of these derivatives was assessed against liver cell line ...
• Synergistic effect of galacto oligosaccharides and iron fortificants on serum iron, ferritin, transferrin and total iron binding capacity levels in anemic rats 

  Ahmad, Abdul Momin Rizwan; Ahmed, Waqas; Iqbal, Sanaullah; Mushtaq, Muhammad Hassan; Anis, Riffat Aysha (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-01)

  Iron deficiency anemia is one of the leading public health issues being faced by the global population currently. The present research was an attempt to determine the synergistic effect of Galacto Oligosaccharides and ...
• Molecular detection of blaNDM and blaVIM in clinically isolated multidrug resistant Escherichia coli in Pakistan 

  Qamar, Muhammad Usman; Mustafa, Ghulam; Qaisar, Uzma; Azeem, Farrukh; Shahid, Muhammad; Manzoor, Irfan; Qasim, Muhammad; Abbas, Tanveer; Shah, Asad Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-13)

  Metallo-β-lactamase (MBL) producing Escherichia coli are an emerging and serious threat to public health sector around the globe. MBL are spreading via plasmids to the host pathogens and produce resistance against carbapenems ...
• Towards fast and cost-effective up-scaling of Nano-encapsulations by Ionic-gelation method using model drug for the treatment of atopic dermatitis 

  Siddique, Muhammad Irfan; Tufail, Saima; Ker, Ze Heng; Khan, Tahir Mehmood; Rasool, Fatima; Sohail, Muhammad Farhan; Shahid, Nabeel (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-13)

  Chitosan nanoparticles (CSNPs) have proven their excellent drug delivery potential through various routes of administration and therefore, the need for large scale production of CSNPs for the commercialization is paramount. ...
• TNF gene promoter region polymorphisms and association with young-onset rheumatoid arthritis 

  Rizvi, Syeda Taskeen Fatima; Arif, Afsheen; Azhar, Abid (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-12)

  Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that shares a major global economic burden due to disabilities and mortality risk. It affects all age groups with a female predominance. Tumor Necrosis Factor ...
• Anti-inflammatory effects of Trigonella gharuensis: Comparative analysis in BALB/C mouse model 

  Mobashar, Aisha; Shabbir, Arham; Hassan, Saeed-ul (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2019-09-11)

  Plants are extensively used in treating inflammatory disorders. The current study focused on evaluating antiinflammatory potential of Trigonella gharuensis. The ethanolic and n-hexane extracts of T. gharuensis were given ...

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