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Total flavonoids, total phenolics, 1-deoxynojirimycin content and alpha-glucosidase inhibitory activity of Thai silkworm races (Bombyx mori Linn.)

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dc.contributor.author Rattana, Surapong
dc.contributor.author Katisart, Teeraporn
dc.contributor.author Butiman, Chirapha
dc.contributor.author Sungthong, Bunleu
dc.date.accessioned 2022-12-02T03:45:47Z
dc.date.available 2022-12-02T03:45:47Z
dc.date.issued 2019-11-01
dc.identifier.citation Rattana, S., Katisart, T., Butiman, C., & Sungthong, B. (2019). Total flavonoids, total phenolics, 1-deoxynojirimycin content and alpha-glucosidase inhibitory activity of Thai silkworm races (Bombyx mori Linn.). Pakistan Journal of Pharmaceutical Sciences, 32(6). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14477
dc.description.abstract The silkworm powder (Bombyx mori Linn.) from Japanese and Korean races has well known used as a blood glucose lowering substance. However, the study of bioactive compounds and hypoglycemic effect on Thai silkworm races is still limited. This study was aimed to investigate the flavonoid, phenolic and 1-deoxynojirimycin (DNJ) contents, and α-glucosidase inhibitory activity of three Thai silkworm races (Nanglai, Nangnoi and Samrong) of the 5th instar, 2nd 4 th day silkworm powders. The total flavonoid, phenolic contents and α-glucosidase inhibitory activity were performed using spectrophotometric methods. The DNJ content was determined using derivatization and further analyzed by HPLC. Nangnoi showed the highest flavonoid content with 12.32±0.41mg quercetin equivalent/g silkworm powder. Nanglai showed the highest phenolic content with 78.74±1.43mg gallic acid equivalent/g silkworm powder. Regarding DNJ content, Nangnoi expressed the highest at 3.11±0.01mg/g silkworm powder. According to the age of silkworm, powders of the instar 5th, day 3rd were provided the highest α-glucosidase inhibitory activity (p<0.05). This study clearly indicated that the 5th instar, 3rd day of Thai silkworms exhibited the highest flavonoid, phenolic, DNJ contents and α-glucosidase inhibitory activity. Further study on blood glucose lowering activity should be performed. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Flavonoids en_US
dc.subject phenolic compounds en_US
dc.subject 1-deoxynojimycin (DNJ) content en_US
dc.subject α-glucosidase inhibitor en_US
dc.subject Thai silkworm (Bombyx mori Linn.) en_US
dc.title Total flavonoids, total phenolics, 1-deoxynojirimycin content and alpha-glucosidase inhibitory activity of Thai silkworm races (Bombyx mori Linn.) en_US
dc.type Article en_US


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