PASTIC Dspace Repository

Assessment of anti-coagulant activity of Nelumbo nucifera fruit

Show simple item record

dc.contributor.author Ali Rajput, Muhammad
dc.contributor.author Alam Khan, Rafeeq
dc.contributor.author Zafar, Shahid
dc.contributor.author Riaz, Azra
dc.contributor.author Ikram, Rahila
dc.date.accessioned 2022-12-02T04:00:35Z
dc.date.available 2022-12-02T04:00:35Z
dc.date.issued 2019-11-04
dc.identifier.citation Rajput, M. A., Khan, R. A., Zafar, S., Riaz, A., & Ikram, R. (2019). Assessment of anti-coagulant activity of Nelumbo nucifera fruit. Pakistan Journal of Pharmaceutical Sciences, 32(6), 2561-2564. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14480
dc.description.abstract The herbal agents rich in flavonoids are progressively becoming popular these days as they are considered to have anti-oxidant effects and also lack bothersome effects. That’s why existing research was encircled around the anticoagulant effect of Nelumbo nucifera fruit (NNF) as it is also a rich source of flavonoids and cultivated in abundance especially in tropical regions of Asia but its usefulness as anti-coagulant agent was never determined pharmacologically. Anticoagulant assessment was done in thirty five male Wister rats which were separated equally in 5 groups. Results of the current study revealed that NNF 200mg/kg significantly prolonged prothrombin time and thrombin time, whereas fibrinogen level was highly significantly reduced as compared to control. Fibrinogen level was also reduced highly significantly with NNF 100 mg/kg as compared to control without affecting other parameters of coagulation i.e. activated partial thromboplastin time, prothrombin time and thrombin time. NNF exhibited strong anti-coagulant activity which may be due to the inhibitory effects on platelet activation, adhesion and aggregation along with inhibitory effects on thromboxane A2 formation. Presence of alkaloid i.e. neferine and flavonoids in it may be a reason of its anti-coagulant activity but more pre-clinical and clinical evaluation needs to be conducted to establish these findings. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Nelumbo nucifera en_US
dc.subject anticoagulant en_US
dc.subject neferine en_US
dc.subject flavonoids en_US
dc.subject hromboxane A2 en_US
dc.title Assessment of anti-coagulant activity of Nelumbo nucifera fruit en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account