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Effect of 3’-4’-dihydroxyflavonol on lipid per oxidation in experimental renal ischemia-reperfusion in rats

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dc.contributor.author Koç, Aynur
dc.contributor.author Ergene, Neyhan
dc.contributor.author Kasim Baltaci, Abdülkerim
dc.contributor.author Mogulkoc, Rasim
dc.date.accessioned 2022-12-02T04:21:10Z
dc.date.available 2022-12-02T04:21:10Z
dc.date.issued 2019-11-07
dc.identifier.citation Koç, A., Ergene, N., Baltaci, A. K., & Mogulkoc, R. (2019). Effect of 3’-4’-dihydroxyflavonol on lipid per oxidation in experimental renal ischemia-reperfusion in rats. Pakistan Journal of Pharmaceutical Sciences, 32(6). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14491
dc.description.abstract This study aimed to examine the affects of 3’-4’-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental renal ischemia-reperfusion. The research was conducted on Wistar-albino type male rat. The experimental groups were formed as 1.Control; 2.Sham; 3.Ischemia; 4.Ischemia+reperfusion; 5.DiOHF+Ischemia; 6.Ischemia+ DiOHF + reperfusion. The highest tissue glutathione levels were found in groups 5 and 6. Groups 1 and 2, which were control and sham groups respectively, had the lowest tissue GSH values. Ischemia group was found to have the highest tissue malondialdehyde (MDA) level. Tissue MDA levels in group 4 were lower than those in group 3, however, higher than the levels in all other groups. Erythrocyte GSH levels in groups 5 and 6 were higher than the levels in all other groups. Group 4 has highest plasma MDA values. Plasma MDA levels in group 3 were lower than the levels in Group 4, but higher than those in other groups. The results of the study indicate that intraperitoneal DiOHF administration inhibits lipid per oxidation that intensifies in the case of renal ischemia-reperfusion injury in rats. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Renal ischemia-reperfusion en_US
dc.subject 3’-4’-Dihydroxyflavonol en_US
dc.subject lipid per oxidation en_US
dc.subject rat en_US
dc.title Effect of 3’-4’-dihydroxyflavonol on lipid per oxidation in experimental renal ischemia-reperfusion in rats en_US
dc.type Article en_US


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