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Preliminary screening of active components in regulating autophagy in Ziziphora clinopodioide Lam.

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dc.contributor.author Zhang, Xuanming
dc.contributor.author An, Dongqing
dc.contributor.author Guo, Longlong
dc.date.accessioned 2022-12-02T04:48:18Z
dc.date.available 2022-12-02T04:48:18Z
dc.date.issued 2019-11-11
dc.identifier.citation Zhang, X., An, D., & Guo, L. (2019). Preliminary screening of active components in regulating autophagy in Ziziphora clinopodioide Lam. Pakistan Journal of Pharmaceutical Sciences, 32(6). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14497
dc.description.abstract Ziziphora clinopodioide Lam, a traditional Chinese medicinal plant, has been used to treat hypertension, coronary heart disease and other cardiovascular diseases, autophagy plays an important role in these diseases. This study investigated the effects of Z. clinopodioides and its active components on autophagy using cell biology. Normal rat kidney (NRK) cells transfected with green fluorescent protein-associated microtubule-protein 1 light Chain 3 (GFPLC3) were intervened with different doses of ethanol and water extracts of Z. clinopodioides and the active components of Z. clinopodioides. After 4 hours treatment, the autophagy spot aggregation in NRK cells was photographed and observed by laser scanning confocal microscopy. The results showed that the water and ethanol extracts of Z. clinopodioides can activate autophagy, the effect of activating autophagy was more significant, when the dose was increased. Five components including chrysin, luteolin, quercetin, oleanolic acid and ursolic acid were identified as the active principles in activating autophagy. This research may provide a reference for the further study of mechanism and material basis of Z. clinopodioides in treatment of cardiovascular diseases. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Ziziphora clinopodioides Lam en_US
dc.subject autophagy en_US
dc.subject screening en_US
dc.title Preliminary screening of active components in regulating autophagy in Ziziphora clinopodioide Lam. en_US
dc.type Article en_US


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