dc.contributor.author |
Ait-kaci Aourahoun, Karima |
|
dc.contributor.author |
Fazouane, Fethia |
|
dc.contributor.author |
Benayache, Samir |
|
dc.contributor.author |
QBettache, Z’Hor |
|
dc.contributor.author |
Benayad, Tahar |
|
dc.contributor.author |
Denni, Nachida |
|
dc.date.accessioned |
2022-12-02T05:24:20Z |
|
dc.date.available |
2022-12-02T05:24:20Z |
|
dc.date.issued |
2019-11-15 |
|
dc.identifier.citation |
Merah, S., Dahmane, D., Krimat, S., Metidji, H., Nouasri, A., Lamari, L., & Dob, T. (2018). Chemical analysis of phenolic compounds and determination of antioxidant, antimicrobial and cytotoxic activities of organic extracts of Pinus coulteri. ||| Bangladesh Journal of Pharmacology|||, 13(2), 120-29. |
en_US |
dc.identifier.issn |
2070-3368 |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/14502 |
|
dc.description.abstract |
Phenolic extracts of aerial parts of Genista ferox have been characterized and evaluated for their
pharmacological properties which are still not reported. The total phenol and flavonoid contents in the extracts were estimated spectrophotometrically via the Folin-Ciocalteu and aluminium chloride methods, respectively. Leaves and pods extracts showed the highest contents of total phenols and total flavonoids. The same extracts exhibited also the highest antioxidant capacity (IC50 of 105.37µg/mL and 113.98µg/mL, respectively) assessed by the in-vitro DPPH radical scavenging method. Leave and stem extracts were explored for their possible anti-inflammatory activity assayed by carrageenan-induced paw edema model. Both extracts (at 400mg/kg) showed edema inhibitory effect, which was found to be close to that of Dichlofenac reference. However, the leave extract produced the highest significant (p<0.001) anti-inflammatory activity when compared with the control. A preliminary characterisation of these phenolic extracts were carried out by high performance liquid chromatography (HPLC) coupled with diode-array detector (DAD), in order to determine the relevance of identified compounds in the pharmacological properties of the plant. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi |
en_US |
dc.subject |
Antioxidant |
en_US |
dc.subject |
anti-inflammatory |
en_US |
dc.subject |
Genista ferox |
en_US |
dc.subject |
phenolics |
en_US |
dc.subject |
HPLC-DAD |
en_US |
dc.title |
Phenolic extracts of aerial parts of Genista ferox have been characterized and evaluated for their pharmacological properties which are still not reported. The total phenol and flavonoid contents in the extracts were estimated spectrophotometrically via the Folin-Ciocalteu and aluminium chloride methods, respectively. Leaves and pods extracts showed the highest contents of total phenols and total flavonoids. The same extracts exhibited also the highest antioxidant capacity (IC50 of 105.37µg/mL and 113.98µg/mL, respectively) assessed by the in-vitro DPPH radical scavenging method. Leave and stem extracts were explored for their possible anti-inflammatory activity assayed by carrageenan-induced paw edema model. Both extracts (at 400mg/kg) showed edema inhibitory effect, which was found to be close to that of Dichlofenac reference. However, the leave extract produced the highest significant (p<0.001) anti-inflammatory activity when compared with the control. A preliminary characterisation of these phenolic extracts were carried out by high performance liquid chromatography (HPLC) coupled with diode-array detector (DAD), in order to determine the relevance of identified compounds in the pharmacological properties of the plant. |
en_US |
dc.type |
Article |
en_US |