dc.contributor.author |
Nafeesa, Khadija |
|
dc.contributor.author |
ur-Rehman, Aziz |
|
dc.contributor.author |
Athar Abbasi, Muhammad |
|
dc.contributor.author |
Zahra Siddiqui, Sabahat |
|
dc.contributor.author |
Rasool, Shahid |
|
dc.contributor.author |
Adnan Ali Shah, Syed |
|
dc.contributor.author |
Ashraf, Muhammad |
|
dc.contributor.author |
Jahan, Bakhat |
|
dc.contributor.author |
Arif Lodhi, Muhammad |
|
dc.contributor.author |
Ali Khan, Farman |
|
dc.date.accessioned |
2022-12-02T05:32:52Z |
|
dc.date.available |
2022-12-02T05:32:52Z |
|
dc.date.issued |
2019-11-16 |
|
dc.identifier.citation |
Rasool, S., Shah, S. A. A., Ashraf, M., Jahan, B., Lodhi, M. A., & Khan, F. A. (2019). α-Glucosidase inhibitory potential and hemolytic evaluation of newly synthesized 3, 4, 5-trisubstituted-1, 2, 4-triazole derivatives. Pak. J. Pharm. Sci, 32(6), 2651-2658. |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/14511 |
|
dc.description.abstract |
A series of 1, 2, 4-triazole derivatives bearing piperidine moiety has been introduced as new anti-diabetic drug
candidates with least cytotoxicity. p-Chlorophenylsulfonyl chloride (1) and ethyl nipecotate (2) were the starting
reagents that resulted into corresponding 3,4,5-trisubstituted-1,2,4-triazole (6) through a series of steps. A series of electrophiles, 9a-e, were synthesized by reacting 4-bromobutyryl chloride (7) with differently substituted aromatic amines (8a-e) under basic aqueous medium. Target derivatives, 10a-e, were synthesized by the reaction of compound 6 with N-aryl-4-bromobutanamides (9a-e) in an aprotic solvent. Structures of all the derivatives were verified by spectroscopic analysis using IR, 1H-NMR, 13C-NMR and EIMS. Most of the derivatives revealed moderate to good αglucosidase inhibitory activity with reference to acarbose. The moderate hemolytic potential demonstrated least toxicity. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi |
en_US |
dc.subject |
1,2,4-Triazoles |
en_US |
dc.subject |
anti α-glucosidase |
en_US |
dc.subject |
hemolytic activity |
en_US |
dc.subject |
sulfonamides |
en_US |
dc.title |
Α-Glucosidase inhibitory potential and hemolytic evaluation of newly synthesized 3, 4, 5-trisubstituted-1, 2, 4-triazole derivatives |
en_US |
dc.type |
Article |
en_US |