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Α-Glucosidase inhibitory potential and hemolytic evaluation of newly synthesized 3, 4, 5-trisubstituted-1, 2, 4-triazole derivatives

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dc.contributor.author Nafeesa, Khadija
dc.contributor.author ur-Rehman, Aziz
dc.contributor.author Athar Abbasi, Muhammad
dc.contributor.author Zahra Siddiqui, Sabahat
dc.contributor.author Rasool, Shahid
dc.contributor.author Adnan Ali Shah, Syed
dc.contributor.author Ashraf, Muhammad
dc.contributor.author Jahan, Bakhat
dc.contributor.author Arif Lodhi, Muhammad
dc.contributor.author Ali Khan, Farman
dc.date.accessioned 2022-12-02T05:32:52Z
dc.date.available 2022-12-02T05:32:52Z
dc.date.issued 2019-11-16
dc.identifier.citation Rasool, S., Shah, S. A. A., Ashraf, M., Jahan, B., Lodhi, M. A., & Khan, F. A. (2019). α-Glucosidase inhibitory potential and hemolytic evaluation of newly synthesized 3, 4, 5-trisubstituted-1, 2, 4-triazole derivatives. Pak. J. Pharm. Sci, 32(6), 2651-2658. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14511
dc.description.abstract A series of 1, 2, 4-triazole derivatives bearing piperidine moiety has been introduced as new anti-diabetic drug candidates with least cytotoxicity. p-Chlorophenylsulfonyl chloride (1) and ethyl nipecotate (2) were the starting reagents that resulted into corresponding 3,4,5-trisubstituted-1,2,4-triazole (6) through a series of steps. A series of electrophiles, 9a-e, were synthesized by reacting 4-bromobutyryl chloride (7) with differently substituted aromatic amines (8a-e) under basic aqueous medium. Target derivatives, 10a-e, were synthesized by the reaction of compound 6 with N-aryl-4-bromobutanamides (9a-e) in an aprotic solvent. Structures of all the derivatives were verified by spectroscopic analysis using IR, 1H-NMR, 13C-NMR and EIMS. Most of the derivatives revealed moderate to good αglucosidase inhibitory activity with reference to acarbose. The moderate hemolytic potential demonstrated least toxicity. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject 1,2,4-Triazoles en_US
dc.subject anti α-glucosidase en_US
dc.subject hemolytic activity en_US
dc.subject sulfonamides en_US
dc.title Α-Glucosidase inhibitory potential and hemolytic evaluation of newly synthesized 3, 4, 5-trisubstituted-1, 2, 4-triazole derivatives en_US
dc.type Article en_US


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