dc.contributor.author |
Hashim, Arshya |
|
dc.contributor.author |
Alvi, Sahir Sultan |
|
dc.contributor.author |
Ansari, Irfan Ahmad |
|
dc.contributor.author |
Khan, M Salman |
|
dc.date.accessioned |
2022-12-02T06:11:44Z |
|
dc.date.available |
2022-12-02T06:11:44Z |
|
dc.date.issued |
2019-11-22 |
|
dc.identifier.citation |
Hashim, A., Alvi, S. S., Ansari, I. A., & Khan, M. S. (2019). Phyllanthus virgatus forst extract and it’s partially purified fraction ameliorates oxidative stress and retino-nephropathic architecture in streptozotocin-induced diabetic rats. Pakistan journal of pharmaceutical sciences, 32(6). |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/14527 |
|
dc.description.abstract |
Diabetic retinopathy and nephropathy are questionably the most dreaded complications of diabetes; contribute
to serious morbidity and mortality. The current study was undertaken with the aim of exploring the anti-lipoperoxidative and antioxidant status including nephroprotective and retinoprotective potential of Phyllanthus virgatus methanolic extract and its partially purified fraction in streptozotocin (STZ)-induced diabetic stressed rats. Diabetes was induced by intraperitoneal injection of Streptozotocin (60mg/kg B. Wt of rat). Among all the treatment groups, P. virgatus methanolic extract and its partially purified fraction at a dose of 50mg/kg (PET-1) and 0.5mg/kg (CT-1), respectively, showed significant protection against STZ-induced diabetic oxidative stress in rats with marked amelioration in lipid peroxidation byproducts level, antioxidant enzymes, nephroprotective and retinoprotective effects and plasma total antioxidant levels after treatment of 28 days. The combined results demonstrated significant protection against STZinduced oxidative stress, nephropathy and retinopathy condition by P. virgatus methanolic extract and its bioactive compound. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi |
en_US |
dc.subject |
Phyllanthus virgatus |
en_US |
dc.subject |
oxidative stress |
en_US |
dc.subject |
nephropathy |
en_US |
dc.subject |
retinopathy |
en_US |
dc.subject |
CD and TBARS |
en_US |
dc.title |
Phyllanthus virgatus forst extract and it’s partially purified fraction ameliorates oxidative stress and retino-nephropathic architecture in streptozotocin-induced diabetic rats |
en_US |
dc.type |
Article |
en_US |