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Phyllanthus virgatus forst extract and it’s partially purified fraction ameliorates oxidative stress and retino-nephropathic architecture in streptozotocin-induced diabetic rats

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dc.contributor.author Hashim, Arshya
dc.contributor.author Alvi, Sahir Sultan
dc.contributor.author Ansari, Irfan Ahmad
dc.contributor.author Khan, M Salman
dc.date.accessioned 2022-12-02T06:11:44Z
dc.date.available 2022-12-02T06:11:44Z
dc.date.issued 2019-11-22
dc.identifier.citation Hashim, A., Alvi, S. S., Ansari, I. A., & Khan, M. S. (2019). Phyllanthus virgatus forst extract and it’s partially purified fraction ameliorates oxidative stress and retino-nephropathic architecture in streptozotocin-induced diabetic rats. Pakistan journal of pharmaceutical sciences, 32(6). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14527
dc.description.abstract Diabetic retinopathy and nephropathy are questionably the most dreaded complications of diabetes; contribute to serious morbidity and mortality. The current study was undertaken with the aim of exploring the anti-lipoperoxidative and antioxidant status including nephroprotective and retinoprotective potential of Phyllanthus virgatus methanolic extract and its partially purified fraction in streptozotocin (STZ)-induced diabetic stressed rats. Diabetes was induced by intraperitoneal injection of Streptozotocin (60mg/kg B. Wt of rat). Among all the treatment groups, P. virgatus methanolic extract and its partially purified fraction at a dose of 50mg/kg (PET-1) and 0.5mg/kg (CT-1), respectively, showed significant protection against STZ-induced diabetic oxidative stress in rats with marked amelioration in lipid peroxidation byproducts level, antioxidant enzymes, nephroprotective and retinoprotective effects and plasma total antioxidant levels after treatment of 28 days. The combined results demonstrated significant protection against STZinduced oxidative stress, nephropathy and retinopathy condition by P. virgatus methanolic extract and its bioactive compound. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Phyllanthus virgatus en_US
dc.subject oxidative stress en_US
dc.subject nephropathy en_US
dc.subject retinopathy en_US
dc.subject CD and TBARS en_US
dc.title Phyllanthus virgatus forst extract and it’s partially purified fraction ameliorates oxidative stress and retino-nephropathic architecture in streptozotocin-induced diabetic rats en_US
dc.type Article en_US


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