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Ameliorating effect of sesamin on insulin resistance of hepatic L02 cells induced by high glucose/high insulin

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dc.contributor.author Mengxi, Wang
dc.contributor.author Mo, Liu
dc.contributor.author Renjie, Zhou
dc.contributor.author Jing, Wu
dc.contributor.author Dongya, Chen
dc.contributor.author Hong, Lei
dc.date.accessioned 2022-12-02T06:28:57Z
dc.date.available 2022-12-02T06:28:57Z
dc.date.issued 2019-11-26
dc.identifier.citation Mengxi, W., Mo, L., Renjie, Z., Jing, W., Dongya, C., & Hong, L. (2019). Ameliorating effect of sesamin on insulin resistance of hepatic L02 cells induced by high glucose/high insulin. Pakistan Journal of Pharmaceutical Sciences, 32(6). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14537
dc.description.abstract Sesamin (SES) has the ameliorating effect on L02 hepatocyte model of insulin resistance induced by high glucose and high insulin, based on insulin receptor signaling pathway IRS/PI3K/Akt. Treatment with SES (200, 100µg/ml) increased glucose consumption, glucose uptake and the intracellular glycogen synthesis of L02 hepatocyte model of insulin resistance significantly. Moreover, treatment with SES promoted the gene and protein expression levels of insulin receptor (InsR) and the post-receptor associated proteins, such as insulin receptor substrate 1 (IRS1), insulin receptor substrate 2 (IRS2), PI3K (phosphatidylinositol 3-kinase), GLUT4 (glucose transporter 4) significantly, which were determined by RT-PCR and immunoblot analysis. In conclusion, SES has the ameliorating effect on L02 hepatocyte model of insulin resistance induced by high glucose/high insulin, which might be related to its effect on promoting expression of insulin receptor and its associated proteins of IRS-PI3K-Akt passway, and thus promoting insulin sensitivity. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Sesamin (SES) en_US
dc.subject insulin resistance en_US
dc.subject L02 hepatocytes en_US
dc.subject insulin receptor en_US
dc.subject IRS/PI3K/Akt signaling pathway en_US
dc.title Ameliorating effect of sesamin on insulin resistance of hepatic L02 cells induced by high glucose/high insulin en_US
dc.type Article en_US


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