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Consciousness inhibition of intravenous dexmedetomidine in patients undergoing lower limb surgery with epidural anesthesia: A doseresponse study by age group

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dc.contributor.author Sun, Qiaoxia
dc.contributor.author Wang, Xueyan
dc.contributor.author Shi, Cunxian
dc.contributor.author Li, Jiang
dc.contributor.author Qu, Hua
dc.contributor.author Ma, Jiahai
dc.date.accessioned 2022-12-02T09:02:16Z
dc.date.available 2022-12-02T09:02:16Z
dc.date.issued 2018-11-20
dc.identifier.citation Sun, Q., Wang, X., Shi, C., Li, T., Jiang, M., Qu, H., & Ma, J. (2018). Consciousness inhibition of intravenous dexmedetomidine in patients undergoing lower limb surgery with epidural anesthesia: A dose-response study by age group. Pakistan Journal of Pharmaceutical Sciences, 31. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14577
dc.description.abstract Dexmedetomidine (DEX) induces a dose dependent sedation and has been widely used as an adjuvant sedative during regional anesthesia recently. We aimed to investigate the effective dose of intravenous single-dose DEX to induce consciousness inhibition in patients of different ages undergoing lower limb surgery with epidural anesthesia. Ninety-two patients were divided into three groups according to their ages. Patients aged 18-45 years, 46-64 years and 65-85 years in group Y, group M and group O, respectively. With the accomplishment of epidural anesthesia, a pre-calculated dose of DEX was infused for more than 10 minutes and the sedative state was assessed by Observer’s Assessment of Alertness/Sedation (OAA/S) scale 30 minutes after the infusion. A modified Dixon’s up-and-down method was applied to decided the dose of DEX for each sequential patient. The 50% effective dose (ED50) of DEX in the three groups were 0.40, 0.76 and 1.03 μg/kg, respectively. The 95% effective dose (ED95) in group O (0.54 μg/kg) was 45% of group Y (1.21μg/kg) and 64% of group M (0.84μg/kg). Besides, the incidence of bradycardia was more frequent with the increase of age. The present study indicated that the appropriate single-dose of DEX to induce consciousness inhibition should reduce with the increase of age in patients undering lower limb surgery with epidural anesthesia, especially in patients over 64 years old. This result may protect the old patients from excessive sedation and dose-dependent adverse reactions en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Dexmedetomidine en_US
dc.subject spinal anesthesia en_US
dc.subject sedation en_US
dc.subject ED50, ED95 en_US
dc.title Consciousness inhibition of intravenous dexmedetomidine in patients undergoing lower limb surgery with epidural anesthesia: A doseresponse study by age group en_US
dc.type Article en_US


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