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Benzothiazine based acetohydrazides and acetamides as anticancer agents

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dc.contributor.author Aslam, Sana
dc.contributor.author Wang, Fang
dc.contributor.author Ahmad, Matloob
dc.contributor.author Zahoor, Ameer Fawad
dc.contributor.author Mansha, Asim
dc.contributor.author Rasul, Azhar
dc.contributor.author Fu, Liwu
dc.date.accessioned 2022-12-05T03:39:46Z
dc.date.available 2022-12-05T03:39:46Z
dc.date.issued 2019-11-04
dc.identifier.citation Aslam, S., Wang, F., Ahmad, M., Zahoor, A. F., Mansha, A., Rasul, A., & Fu, L. (2019). Benzothiazine based acetohydrazides and acetamides as anticancer agents. Pak J Pharm Sci, 32(6), 2795-2800. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14589
dc.description.abstract Four series of pyrazolobenzothiazine derivatives were evaluated for their anticancer activity against six different cancer cell lines i.e., KB (human oral carcinoma cells), MCF-7(human breast carcinoma cells), A549 (human alveolar adenocarcinoma cells), Hep-G2 (liver carcinoma cells), SGC-7901(human gastric carcinoma cells) and S1 (human colon carcinoma cells) using MTT assay. Among eighteen compounds tested, six compounds i.e., 1a, 1b, 1d, 4a, 4d and 4e were more active than 5-florouracil against human oral carcinoma cells (KB). Moreover, compounds 2b and 2c showed activity comparable to 5-FU against KB cell line. In addition, eight compounds were non-toxic to human PBM cells and thus exhibit selective anticancer activity. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Pyrazolobenzothiazine ring system en_US
dc.subject 1,2-Benzothiazine 1,1-dioxide en_US
dc.subject anticancer activity en_US
dc.title Benzothiazine based acetohydrazides and acetamides as anticancer agents en_US
dc.type Article en_US


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