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The therapeutic and antineoplastic effects of vitamin B17 against the growth of solid-form Ehrlich tumours and the associated changes in oxidative stress, DNA damage, apoptosis and proliferation in mice

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dc.contributor.author El-Masry, Thanaa A.
dc.contributor.author Al-Shaalan, Nora H.
dc.contributor.author Tousson, Ehab
dc.contributor.author Buabeid, Manal
dc.contributor.author Alyousef, Anhar M.
dc.date.accessioned 2022-12-05T03:43:54Z
dc.date.available 2022-12-05T03:43:54Z
dc.date.issued 2019-11-05
dc.identifier.citation El-Masry, T. A., Al-Shaalan, N. H., Tousson, E., Buabeid, M., & Alyousef, A. M. (2019). The therapeutic and antineoplastic effects of vitamin B17 against the growth of solid-form Ehrlich tumours and the associated changes in oxidative stress, DNA damage, apoptosis and proliferation in mice. Pak. J. Pharm. Sci, 32(6), 2801-2810. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14590
dc.description.abstract Many cancer therapies indirectly activate apoptosis by chemical or physical damage of DNA. This study was performed to evaluate protective potential of vitamin B17 (VitB17) against Ehrlich solid tumor (EST) induced changes in the oxidative stress, DNA damage, apoptosis and proliferation in mice. In the experiment, 60 female CD1 mice were randomly and allocated to the following four equal-sized groups [G1, negative control; G2, positive control (VitB17); G3, untreated EST; G4, EST treated with VitB17 (EST+VitB17)]. The untreated EST group displayed major increases in tumor volume, significant increase in the levels of MDA, H2O2, NO, PCNA, TNF-α, AFP and dsDNA and notable reductions in the catalase, GSH, P53 and SOD activities. By contrast, reduced levels of TNF-α, AFP, MDA, H2O2, NO, PCNA and dsDNA, along with enhanced levels of P53 and the antioxidant indicators catalase, GSH and SOD were observed in the EST+VitB17 group. These results indicate the antineoplastic and antioxidant properties of vitamin B17 with the potential to decrease the oxidative stress associated with ESTs by augmenting the antioxidant defence system. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Ehrlich solid tumour en_US
dc.subject vitamin B17 en_US
dc.subject cytokines en_US
dc.subject oxidative stress en_US
dc.subject DNA damage proliferation and apoptotic markers. en_US
dc.title The therapeutic and antineoplastic effects of vitamin B17 against the growth of solid-form Ehrlich tumours and the associated changes in oxidative stress, DNA damage, apoptosis and proliferation in mice en_US
dc.type Article en_US


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