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Antidiabetic potential of flavonoids from Artemisia macrocephalla Jaquem in streptozotocin-induced diabetic rats: Pharmacological and biochemical approach

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dc.contributor.author Shah, Syed Wadood Ali
dc.contributor.author Ghias, Mehreen
dc.contributor.author Shoaib, Mohammad
dc.contributor.author Ali, Niaz
dc.contributor.author Shah, Ismail
dc.contributor.author Umar, Muhammad Naveed
dc.contributor.author Shah, Syed Muhammad Mukarram
dc.contributor.author Shah, Syed Muhammad Hassan
dc.contributor.author Khan, Wali
dc.contributor.author Khan, Shahzeb
dc.contributor.author Jan, Tour
dc.contributor.author Ahmad, Saeed
dc.contributor.author Shakirullah, Shakirullah
dc.contributor.author Shafiullah, Shafiullah
dc.date.accessioned 2022-12-05T04:38:25Z
dc.date.available 2022-12-05T04:38:25Z
dc.date.issued 2019-11-14
dc.identifier.citation Shah, S. W. A., Ghias, M., Shoaib, M., Ali, N., Shah, I., Umar, M. N., ... & Ahmad, S. (2019). Antidiabetic potential of flavonoids from Artemisia macrocephalla Jaquem in streptozotocin-induced diabetic rats: Pharmacological and biochemical approach. Pakistan Journal of Pharmaceutical Sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14602
dc.description.abstract Plants belongs to Asteraceae family are reported to be rich in major phytochemical including flavonoids and are documented to acquire antidiabetic response. Antidiabetic effects of salvigenin, eupatilin and cirsilineol were screened on in-vitro enzyme inhibition and in-vivo streptozotocin animal models. Administration of salvigenin, eupatilin and cirsilineol (7.5 and 15mg/kg) produced antidiabteic responses in streptozotocin model for diabetes. All natural flavonoids reduces the blood glucose level to a significant level (*P<0.05, **P<0.01, ***P<0.001, n=8) but promising results were observed in eupatilin at dose of 7.5mk/kg (364.12±4.3 to 128.41±4.2mg/dL, n=8) and at dose of 7.5mk/kg 363.65±4.8 to 126.14±5.1mg/dL, n=8). Administration of salvigenin, eupatilin and cirsilineol (7.5 and 15mg/kg) for 28 days showed a substantial fall (*P<0.05, **P<0.01, ***P<0.001, n=8) in total cholesterol, LDL and triglcerides (TGs) in comparison to diabetic model. The isolated flavonoids reduced considerably the serum ALP, SGPT and SGOT in rats intoxicated with streptozotocin. The results indicate that the flavonoids may be useful in the development of new antidiabetic drugs. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Artemisia en_US
dc.subject isolated flavonoids en_US
dc.subject enzyme inhibition en_US
dc.subject diabetes en_US
dc.subject streptozotocin. en_US
dc.title Antidiabetic potential of flavonoids from Artemisia macrocephalla Jaquem in streptozotocin-induced diabetic rats: Pharmacological and biochemical approach en_US
dc.type Article en_US


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