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Ex-vivo antihypertensive and calcium channel blocking activity of Androsace foliosa n-hexane leaves fraction on isolated rabbit aorta

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dc.contributor.author Zaheer, Jawad
dc.contributor.author Kausar, Abida
dc.contributor.author Kanwa, Hina
dc.contributor.author Akhtar, Noreen
dc.contributor.author Ilyas, Aisha
dc.contributor.author Nazlli, Zil-I-Huma
dc.contributor.author Riaz, Ayesha
dc.contributor.author Shah, Syed Muhammad Ali
dc.contributor.author Akram, Muhammad
dc.contributor.author Sarwar, Muhammad Usman
dc.contributor.author Khan, Abdul Hamid
dc.contributor.author Khan, Fahad Said
dc.contributor.author Asad, Farhan
dc.contributor.author Anwar, Hina
dc.contributor.author Anwar, Madeeha
dc.date.accessioned 2022-12-05T05:00:26Z
dc.date.available 2022-12-05T05:00:26Z
dc.date.issued 2019-11-18
dc.identifier.citation Zaheer, J., Kausar, A., Kanwal, H., Akhtar, N., Ilyas, A., Nazlli, Z. I., ... & Anwar, M. (2019). Ex-vivo antihypertensive and calcium channel blocking activity of Androsace foliosa n-hexane leaves fraction on isolated rabbit aorta. Pak. J. Pharm. Sci, 32(6), 2893-2898. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14609
dc.description.abstract Hypertension is persistent elevation in blood pressure for 3-4 weeks. Estimated global prevalence of hypertension suggested that by the Year 2025 (29%) of adult worldwide are suffering from hypertension (1.56 billion). Hypertension complications are hemorrhage, atherosclerosis, renal artery stenosis, angina pectoris end organ damage, cardiomyopathy, myocardial infarction and retinopathy. Along with other drug class Calcium channel blocker are also used for the treatment of hypertension. In this study the possible action of the n-hexane leaves fraction of the Androsace foliosa on isolated rabbit aorta was examined. Antihypertensive activity was examined in the existence of standard agonist like phenylephrine and antagonist like Verapamil. Phenylephrine (PE 1µM) high K+ was used to steady the tissue materials. Additionally to observe the calcium channel blocking effect the tissues were treated with n-hexane segment of A. foliosa leaves. Aortic tissues were treated 4-5intervals with Ca+2- free preparation earlier to control calcium reaction curve (CRCs). Verapamil is utilized as standard calcium channel inhibitory mediator and is used as an antagonist. The Af. n-hexane leaves fraction completely inhibited the precontractions induced by Phenylephrine (1µM) and K+ (80 mM) precontractions, with EC50 standards of 1.0mM (0.3-1.0mg/mL) and 4.90mM (1-3mg/mL), espectively. Androsace foliosa n-hexane leaves fraction was tested for calcium channel inhibitory effect on isolated rabbit aorta. A. foliosa nhexane leaves segment at the dosage of 1mg/mL block the calcium channel approximately (35±5%). Consequence indicates that A. foliosa n-hexane leaves segment block calcium channel in the similar manner as compared to the standard calcium channel blocker drug (verapamil). en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Androsace foliosa en_US
dc.subject hypertension en_US
dc.subject phenylephrine en_US
dc.subject verapamil en_US
dc.subject calcium channel blocker en_US
dc.title Ex-vivo antihypertensive and calcium channel blocking activity of Androsace foliosa n-hexane leaves fraction on isolated rabbit aorta en_US
dc.type Article en_US


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