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PROCESS OPTIMIZATION OF CITRIC ACID PRODUCTION FROM ASPERGILLUS NIGER USING FUZZY LOGIC DESIGN

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dc.contributor.author ALI, SIKANDER
dc.contributor.author IKRAM UL HAQ, IKRAM UL HAQ
dc.date.accessioned 2022-12-05T09:23:05Z
dc.date.available 2022-12-05T09:23:05Z
dc.date.issued 2014-07-07
dc.identifier.citation Sikander, A. (2014). Process optimization of citric acid production from Aspergillus niger using fuzzy logic design. Pakistan Journal of Botany, 46(5), 1899-1903. en_US
dc.identifier.issn 2070-3368
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14664
dc.description.abstract The inherent non-linearity of citric acid fermentation from Aspergillus niger renders its control difficult, so there is a need to fine-tune the bioreactor performance for maximum production of citric acid in batch culture. For this, fuzzy logic is becoming a popular tool to handle non-linearity of a batch process. The present manuscript deals with fuzzy logic control of citric acid accretion by A. niger in a stirred tank reactor using blackstrap sugarcane molasses as a basal fermentation medium. The customary batches were termed as ‘control’ while those under fuzzy logic were ‘experimental’. The performance of fuzzy logic control of stirred tank reactor was found to be very encouraging for enhanced production of citric acid. The comparison of kinetic parameters showed improved citrate synthase ability of experimental culture (Yp/x = 7.042 g/g). When the culture grown on 150 g/l carbohydrates was monitored for Qp, Qs and Yp/s, there was significant enhancement in these variables over the control. Specific productivity of culture (qp = 0.070 g/g cells/h) was several fold increased. The enthalpy (ΔHD = 70.5 kJ/mol) and entropy of activation (ΔS = -144 J/mol/K) of enzyme for citric acid biosynthesis, free energies for transition state formation and substrate binding for sucrose hydrolysis of experimental were substantially improved. en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Journal of Botany, botanical garden, university of karachi en_US
dc.title PROCESS OPTIMIZATION OF CITRIC ACID PRODUCTION FROM ASPERGILLUS NIGER USING FUZZY LOGIC DESIGN en_US
dc.type Article en_US


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