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Ex-vivo abortifacient activity of Androsace foliosa n-hexane leaves extract on isolated rabbit uterus

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dc.contributor.author Zaheer, Jawad
dc.contributor.author Saqib, Qazi Najam-Us-
dc.contributor.author Hashmi, Asif Mehmmod
dc.contributor.author Mukhtiar, Muhammad
dc.contributor.author Zafar, Sadia
dc.contributor.author Riaz, Muhammad
dc.contributor.author Rasool, Ghulam
dc.contributor.author Akram, Muhammad
dc.contributor.author Shah, Syed Muhammad Ali
dc.contributor.author Rahat, Saher
dc.contributor.author Khan, Faid Said
dc.date.accessioned 2022-12-05T09:34:17Z
dc.date.available 2022-12-05T09:34:17Z
dc.date.issued 2019-09-18
dc.identifier.citation Zaheer, J., Najam-Us-Saqib, Q., Hashmi, A. M., Mukhtiar, M., Zafar, S., Riaz, M., ... & Khan, F. S. (2019). Ex-vivo abortifacient activity of Androsace foliosa n-hexane leaves extract on isolated rabbit uterus. Pak. J. Pharm. Sci, 32(5), 2333-2339. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14665
dc.description.abstract Androsace foliosa is a medicinal herb utilized in different areas of Pakistan for abortifacient, diabetic and liver complications. In the current research, the possible action of the n-hexane leaves extract of the Androsace foliosa on isolated rabbit uterus was examined. Abortifacient activity was examined in the existence of standard antagonist e.g. atropine and salbutamol and a uterine tonic like oxytocin. The isolated rabbit uterus is initially treated with 1mg/kg stilboesterol for 1 complete day. The consequence of oxytocin as uterine contraction agonist was observed. Additionally, antagonists e.g. salbutamol (2µg) and atropine (1-2mg) on the uterine contractile action of the extract were also examined. The A. foliosa n-hexane leaves extract fashion dose correlated amplification in the force of uterine contraction comparable to oxytocin. The drug oxytocin was pragmatic to amplify the uterine contractile action of the extract. Meanwhile pre-treating the tissue with either atropine or salbutamol earlier than administrating the extract indicates the inhibitory action of the drugs on the action of the extract. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Androsace foliosa en_US
dc.subject uterine contraction en_US
dc.subject oxytocin en_US
dc.subject atropine en_US
dc.subject salbutamol en_US
dc.subject prostaglandin en_US
dc.title Ex-vivo abortifacient activity of Androsace foliosa n-hexane leaves extract on isolated rabbit uterus en_US
dc.type Article en_US


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