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Pharmacological basis for the medicinal use of Alcea rosea in airways disorders and chemical characterization of its fixed oils through GCMS

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dc.contributor.author Hanif, Muhammad
dc.contributor.author Mehmood, Malik Hassan
dc.contributor.author Ishrat, Ghazala
dc.contributor.author Virji, Safna Naozer
dc.contributor.author Malik, Abdul
dc.contributor.author Ahmed, Mansoor
dc.contributor.author Gilani, Anwarul-Hassan
dc.date.accessioned 2022-12-05T09:42:57Z
dc.date.available 2022-12-05T09:42:57Z
dc.date.issued 2019-09-20
dc.identifier.citation Hanif, M., Mehmood, M. H., Ishrat, G., Virji, S. N., Malik, A., Ahmed, M., & Gilani, A. H. (2019). Pharmacological basis for the medicinal use of Alcea rosea in airways disorders and chemical characterization of its fixed oils through GC-MS. Pak. J. Pharm. Sci, 32(5), 2347-2355. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14667
dc.description.abstract Alcea rosea L. also known as Althea rosea belongs to the Malvaceae family. This medicinal herb, traditionally used to treat several conditions including airway disorders like asthma and chronic bronchitis. This study evaluated the bronchodilatory effects and possible mechanism of A. rosea on guinea-pig tracheal tissues. Moreover lipophilic profiling of A. rosea has been carried out by using Gas-Chromatography-Mass-Spectrometry. A total of 19 compounds have been identified from the plant, n-hexane fraction. These compounds have been further confirmed from their Van den Dool and Kratz (I) Indices. Major class of metabolite identified from the plant includes fatty acid, saturated and unsaturated fatty acid esters. Hydrocarbons have also been detected from the n-hexane fraction. These fatty acid esters have not been reported previously by GC-MS and were identified first time from the flowers of Alcea rosea. In-vitro experiments were performed on guinea-pig tracheal tissues, mounted in Kreb’s solution at 37°C and bubbled with carbogen. In isolated guinea-pig trachea, A. rosea inhibited carbamylcholine and K+ (80 mM)-induced contractions, potentiated isoprenaline concentration-response curves (CRCs) and suppressed Ca2+ CRCs. These results suggest that A. rosea cause bronchodilation through dual inhibition of phosphodiesterase enzyme and Ca2+ influx, which substantiate its potential in airways disorders. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Alcea rosea en_US
dc.subject bronchodilator en_US
dc.subject phosphodiesterase inhibitor en_US
dc.subject calcium channel blocker en_US
dc.subject GC-MS analysis en_US
dc.title Pharmacological basis for the medicinal use of Alcea rosea in airways disorders and chemical characterization of its fixed oils through GCMS en_US
dc.type Article en_US


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