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Polymorphism of Interleukin-10 (IL-10, -1082 G/A) and Interleukin28B (IL-28B, C/T) in pediatric Acute Lymphoblastic Leukemia (ALL)

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dc.contributor.author Ghufran, Hafiz
dc.contributor.author Riaz, Sehar
dc.contributor.author Mahmood, Nasir
dc.contributor.author Yaqoob, Muhammad
dc.contributor.author Shahid, Saman
dc.contributor.author Bhinder, Munir Ahmad
dc.contributor.author Anwar, Saadia
dc.contributor.author Faizan, Mahwish
dc.date.accessioned 2022-12-05T09:49:18Z
dc.date.available 2022-12-05T09:49:18Z
dc.date.issued 2019-09-21
dc.identifier.citation Syedbasha, M. (2019). The immune modulatory role of interferon lambda on human B-cell functions (Doctoral dissertation, University_of_Basel). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14668
dc.description.abstract We conducted genotypic analyses of interleukin-10 (IL-10) (-1082 G/A; GG, GA, AA) and interleukin-28B (CC, CT, TT) genes polymorphisms in acute lymphoblastic leukemia (ALL) pediatric patients in descriptive study to evaluate the prevalence of these mutations. In amplification refractory mutation system-PCR (ARMS-PCR), one reaction was carried out for each patient’s DNA sample. For IL-28B gene, two forward and two reverse primers specific for Callele and T-allele were used separately. For human IL-10 gene, two different forward primers specific for A and G alleles were used in combination with common reverse primer. IL-10 gene promoter showed highest frequency (n=29, 58%) of heterozygous (GA) allele, while genotypic analysis of IL-28B gene showed highest frequency (n=28, 56%) of homozygous (CC) allele. The IL-10 (AA) genotype related to its protein’s less production in body which may be associated with the least survival of ALL’s patients, while IL-28b (CT and TT) genotypes may be associated with less IFNλ3 levels and less life expectancy. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Acute lymphoblastic leukemia (ALL) en_US
dc.subject Interleukin 10 (IL-10) en_US
dc.subject Interleukin 28B (IL-28B) en_US
dc.subject Single nucleotide polymorphism (SNP) en_US
dc.title Polymorphism of Interleukin-10 (IL-10, -1082 G/A) and Interleukin28B (IL-28B, C/T) in pediatric Acute Lymphoblastic Leukemia (ALL) en_US
dc.type Article en_US


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