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Development, characterization and evaluation of in-vitro anti-inflammatory activity of ginger extract based micro emulsion

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dc.contributor.author Akram, Ayesha
dc.contributor.author Rasul, Akhtar
dc.contributor.author Waqas, Muhammad Khurram
dc.contributor.author Irfan, Muhammad
dc.contributor.author Khalid, Syed Haroon
dc.contributor.author Aamir, Muhammad Naeem
dc.contributor.author Murtaza, Ghulam
dc.contributor.author Rehman, Kashif Ur
dc.contributor.author Iqbal, Muhammad
dc.contributor.author Khan, Barkat Ali
dc.date.accessioned 2022-12-06T03:46:22Z
dc.date.available 2022-12-06T03:46:22Z
dc.date.issued 2019-05-08
dc.identifier.citation Akram, A., Rasul, A., Waqas, M. K., Irfan, M., Khalid, S. H., Aamir, M. N., ... & Khan, B. A. (2019). Development, characterization and evaluation of in-vitro anti-inflammatory activity of ginger extract based micro emulsion. Pakistan Journal of Pharmaceutical Sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14676
dc.description.abstract Zingeber officinale is a commonly used plant which has been shown to possess anti-inflammatory activity. The active compounds present in ginger are gingerols, shagaols and paradol. The aim of this study was formulation of topical microemulsion system to enhance the solubility and stability of ginger extract, as it is unstable in the presence of light, air, heat and long term storage, and to evaluate its anti-inflammatory activity. The solubility of ginger extract in different oils, surfactants, and co-surfactants was determined in order to find the optimal components for microemulsion. IPM was selected as oil phase, tween 80 and PEG 400 were selected as surfactant and co-surfactant respectively based on highest solubility values. Pseudo-ternary phase diagram was constructed in order to find out the microemulsion region. The prepared microemulsions were evaluated for pH, viscosity, conductivity, refractive index, globular size, zeta potential, polydispersity index, ginger extract content. The formulation F1 showed best physicochemical properties with smallest globular size. It also showed significant (p<0.05) anti-inflammatory effect as compared to reference piroxicam drug solution. Based on the results, it is concluded that ginger extract can be used to develop stable microemulsion system and promising anti-inflammatory activity. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Anti-inflammatory activity en_US
dc.subject ginger extract en_US
dc.subject O/W micro emulsion en_US
dc.subject Pseudo-ternary phase diagram en_US
dc.subject surfactant en_US
dc.title Development, characterization and evaluation of in-vitro anti-inflammatory activity of ginger extract based micro emulsion en_US
dc.type Article en_US


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