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Antibacterial, antidiarrheal, anti-inflammatory and analgesic activities of compound Shikuqin powder

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dc.contributor.author Yu, Bo
dc.contributor.author Yu, Jiankang
dc.contributor.author Jiang, Lingling
dc.contributor.author Chen, Xiangxiu
dc.contributor.author Song, Xu
dc.contributor.author Zhou, Sixuan
dc.contributor.author Xu, Jinge
dc.contributor.author Wu, Jie
dc.contributor.author Tu, Zhiqiang
dc.contributor.author Song, Zhiling
dc.contributor.author Yin, Zhongqiong
dc.contributor.author Shang, Yishun
dc.date.accessioned 2022-12-06T03:54:10Z
dc.date.available 2022-12-06T03:54:10Z
dc.date.issued 2019-05-09
dc.identifier.citation Yu, B., Yu, J., Jiang, L., Chen, X., Song, X., Zhou, S., ... & Shang, Y. (2019). Antibacterial, antidiarrheal, anti-inflammatory and analgesic activities of compound Shikuqin powder. Pakistan Journal of Pharmaceutical Sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14677
dc.description.abstract The MIC and MBC values of Shikuqin (SKQ) against 5 bacteria that readily cause diarrhea were measured by the broth micro dilution method. The castor oil-induced diarrhea method was used to evaluate the antidiarrheal activity. Intestinal transit and gastric emptying were also evaluated with normal and neostigmine-induced intestinal transit in rodents. In addition, the antidiarrheal activity of SKQ was assessed in vivo with isolated rabbit ileum. Xylene-induced ear edema was used to evaluate the anti-inflammatory activities in mice, while hot plate and writhing tests were performed to assess the analgesic effects. Senna decoction (0.3g/mL) was administered intragastrically to induce a rat model of diarrhea. Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to detect AQP4 mRNA, and Western blot was performed to quantify the protein level of AQP4 in the colon. SKQ exhibits remarkable antidiarrheal, anti-inflammatory and analgesic effects in the gastrointestinal tract disorders, and can therefore be developed as a promising antidiarrheal agent. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Analgesic en_US
dc.subject antibacterial en_US
dc.subject antidiarrheal en_US
dc.subject anti-inflammatory en_US
dc.subject compound Shikuqin powder en_US
dc.title Antibacterial, antidiarrheal, anti-inflammatory and analgesic activities of compound Shikuqin powder en_US
dc.type Article en_US


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