dc.contributor.author |
Yu, Bo |
|
dc.contributor.author |
Yu, Jiankang |
|
dc.contributor.author |
Jiang, Lingling |
|
dc.contributor.author |
Chen, Xiangxiu |
|
dc.contributor.author |
Song, Xu |
|
dc.contributor.author |
Zhou, Sixuan |
|
dc.contributor.author |
Xu, Jinge |
|
dc.contributor.author |
Wu, Jie |
|
dc.contributor.author |
Tu, Zhiqiang |
|
dc.contributor.author |
Song, Zhiling |
|
dc.contributor.author |
Yin, Zhongqiong |
|
dc.contributor.author |
Shang, Yishun |
|
dc.date.accessioned |
2022-12-06T03:54:10Z |
|
dc.date.available |
2022-12-06T03:54:10Z |
|
dc.date.issued |
2019-05-09 |
|
dc.identifier.citation |
Yu, B., Yu, J., Jiang, L., Chen, X., Song, X., Zhou, S., ... & Shang, Y. (2019). Antibacterial, antidiarrheal, anti-inflammatory and analgesic activities of compound Shikuqin powder. Pakistan Journal of Pharmaceutical Sciences, 32. |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/14677 |
|
dc.description.abstract |
The MIC and MBC values of Shikuqin (SKQ) against 5 bacteria that readily cause diarrhea were measured by
the broth micro dilution method. The castor oil-induced diarrhea method was used to evaluate the antidiarrheal activity. Intestinal transit and gastric emptying were also evaluated with normal and neostigmine-induced intestinal transit in rodents. In addition, the antidiarrheal activity of SKQ was assessed in vivo with isolated rabbit ileum. Xylene-induced ear edema was used to evaluate the anti-inflammatory activities in mice, while hot plate and writhing tests were performed to assess the analgesic effects. Senna decoction (0.3g/mL) was administered intragastrically to induce a rat model of diarrhea. Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to detect AQP4 mRNA, and Western blot was performed to quantify the protein level of AQP4 in the colon. SKQ exhibits remarkable antidiarrheal, anti-inflammatory and analgesic effects in the gastrointestinal tract disorders, and can therefore be developed as a promising antidiarrheal agent. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi |
en_US |
dc.subject |
Analgesic |
en_US |
dc.subject |
antibacterial |
en_US |
dc.subject |
antidiarrheal |
en_US |
dc.subject |
anti-inflammatory |
en_US |
dc.subject |
compound Shikuqin powder |
en_US |
dc.title |
Antibacterial, antidiarrheal, anti-inflammatory and analgesic activities of compound Shikuqin powder |
en_US |
dc.type |
Article |
en_US |