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Effect of dexmedetomidine combined with oxycodone patientcontrolled intravenous analgesia on the levels of inflammatory cytokine in patients with rectal cancer

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dc.contributor.author Song, Junnian
dc.contributor.author Wei, Na
dc.contributor.author Zhang, Jing
dc.contributor.author Wang, Gang
dc.date.accessioned 2022-12-06T04:33:01Z
dc.date.available 2022-12-06T04:33:01Z
dc.date.issued 2019-05-16
dc.identifier.citation Song, J., Wei, N., Zhang, J., & Wang, G. (2019). Effect of dexmedetomidine combined with oxycodone patientcontrolled intravenous analgesia on the levels of inflammatory cytokine in patients with rectal cancer. Pakistan Journal of Pharmaceutical Sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14685
dc.description.abstract This study was designed to discuss the clinical effects of dexmedetomidine combined with oxycodone patientcontrolled intravenous analgesia for patients with laparoscopic radical resection of rectal cancer. A total of 90 patients with rectal cancer undergoing laparoscopic radical resection surgery were selected. The patients were divided into A, B and C group using a random number table method, 30 cases in each group. Patients in group A received oxycodone (O) alone postoperatively; patients in group B received dexmedetomidine combined with oxycodone (DO) postoperatively; and patients in group C received dexmedetomidine (D) alone postoperatively. The Visual Analog Scale (VAS) score and Ramsay sedative score at 2h, 6h, 24h and 48h after surgery were evaluated, and the effective compressions number of controlled intravenous analgesia (CIA) was recorded. The occurrence of side effects including fever, nausea, vomiting, drowsiness, dizziness, itchy skin, respiratory depression and other adverse reactions were noted. CRP, TNF-α, and IL-6 were detected by ELISA prior to surgery and on the morning of the 1st and the 3rd day after surgery, respectively. VAS scores in group B were lower than group A and C, the effective compressions number of CIA in group B was less than group A and C, the incidence of adverse reactions in group B was lower than group A and group C. The levels of CRP, TNF-α and IL-6 at 72h after surgery in group B were lower than group A and C. Dexmedetomidine combined with oxycodone has better sedative and analgesic effects with less adverse reactions, it can reduce the release of inflammatory cytokines of CRP, TNF-α and IL-6 in the body and has certain clinical application value. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Dexmedetomidin en_US
dc.subject oxycodone en_US
dc.subject radical resection en_US
dc.title Effect of dexmedetomidine combined with oxycodone patientcontrolled intravenous analgesia on the levels of inflammatory cytokine in patients with rectal cancer en_US
dc.type Article en_US


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