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Analysis of the effect of methyl 2-acetamide-3-methylquinoxaline-7- carboxylate 1,4-di-N-oxide on the relative expression of the trypanothione reductase gene in Trypanosoma cruzi epimastigotes

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dc.contributor.author Vazquez-Jimenez, Lenci K
dc.contributor.author Hernandez-Posada, María I
dc.contributor.author Paz-Gonzalez, Alma D
dc.contributor.author Nogueda-Torres, Benjamín
dc.contributor.author Martinez-Vazquez, Ana V
dc.contributor.author Herrera-Mayorga, Veronica
dc.contributor.author Bocanegra-Garcia, Virgilio
dc.contributor.author Rivera, Gildardo
dc.date.accessioned 2022-12-06T05:18:47Z
dc.date.available 2022-12-06T05:18:47Z
dc.date.issued 2019-05-27
dc.identifier.citation Vazquez-Jimenez, L. K., Hernandez-Posada, M. I., Paz-Gonzalez, A. D., Nogueda-Torres, B., Martinez-Vazquez, A. V., Herrera-Mayorga, V., ... & Rivera, G. (2019). Analysis of the effect of methyl 2-acetamide-3-methylquinoxaline-7-carboxylate 1, 4-di-N-oxide on the relative expression of the trypanothione reductase gene in Trypanosoma cruzi epimastigotes. Pakistan journal of pharmaceutical sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14722
dc.description.abstract In recent decades, some quinoxaline 1,4-di-N-oxide derivatives have been shown to have better trypanocidal activity than the reference drugs; however, their mechanism of action is not yet clear, although it is suggested that they mainly produce reactive oxygen species that cause oxidative stress and parasite death. Trypanosoma cruzi relies on the enzyme trypanothione reductase, among others, to defend itself against oxidative stress. With the aim of contributing to the elucidation of the mechanism of action of quinoxaline 1,4-di-N-oxide derivatives on Trypanosoma cruzi, this study was carried out to evaluate the effect of methyl 2-amide-3-methylquinoxaline-7-carboxylate 1,4-di-N-oxide (compound M-8) on the expression of the trypanothione reductase gene in an in vitro model on Trypanosoma cruzi epimastigotes of the CL-Brener strain. The results show that compound M-8 does not cause a significant effect on the trypanothione reductase gene, suggesting a mechanism of action not related to oxidative stress. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Gene expression en_US
dc.subject quinoxaline en_US
dc.subject 1,4-di-N-oxide en_US
dc.subject trypanothione reductase en_US
dc.subject Trypanosoma cruzi en_US
dc.subject Chagas disease en_US
dc.title Analysis of the effect of methyl 2-acetamide-3-methylquinoxaline-7- carboxylate 1,4-di-N-oxide on the relative expression of the trypanothione reductase gene in Trypanosoma cruzi epimastigotes en_US
dc.type Article en_US


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