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Impact of formulation variables on weight uniformity of scored tablets using factorial design

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dc.contributor.author Zaid, Abdel Naser
dc.contributor.author Hawari, Raghda
dc.contributor.author Malkieh, Numan
dc.contributor.author Natshih, Yasmin
dc.contributor.author Yousef, Abeer
dc.contributor.author Jaradat, Nidal
dc.contributor.author Hammad, Aysha
dc.contributor.author Basharat, Rebhi
dc.date.accessioned 2022-12-06T07:00:47Z
dc.date.available 2022-12-06T07:00:47Z
dc.date.issued 2019-09-20
dc.identifier.citation Zaid, A. N., Hawari, R., Malkieh, N., Natshih, Y., Yousef, A., Jaradat, N., ... & Basharat, R. (2019). Impact of formulation variables on weight uniformity of scored tablets using factorial design. Pakistan Journal of Pharmaceutical Sciences, 32(SI5), 2501-2508. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14749
dc.description.abstract Maintaining safety and efficacy is an important task when splitting a tablet. This Pharmacy practice affords the patient with unavailable required dose, easy swallowing, and cost-saving measure. To access the role of formulation variables on the weight uniformity test of halves tablets. Uncoated and coated placebo tablets were prepared using wet granulation technique. After compression, hardness, disintegration time, friability and weight variation were evaluated according to the USP test. Both coated and uncoated tablets were dived and the obtained halves were weighed and the uniformity of halves was assessed for each kind of tablets. Despite the hardness, size, tablet shape (oval, disc, capsule), all of them passed the splitting test except for the disc shape which showed %RSD higher than 6%. However, hardness and the coating had a generally positive trend on tablet breaking since they gave low% RSD. These findings suggest that the disc shape particle is not suitable for breaking. In addition, film coating, as well as high hardness may give better uniformity of the obtained halves, since a decrease in the calculated %RSD was observed. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Tablet en_US
dc.subject weight uniformity, halves en_US
dc.subject manufacturing, factorial design en_US
dc.title Impact of formulation variables on weight uniformity of scored tablets using factorial design en_US
dc.type Article en_US


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