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Evaluation of prokinetic and laxative effects of Hippophae rhamnoides in rodents

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dc.contributor.author Hanif, Muhammad
dc.contributor.author Mehmood, Malik Hassan
dc.contributor.author Ishrat, Ghazala
dc.contributor.author Abdullah, Ahmed
dc.contributor.author Sohail, Samar
dc.contributor.author Ahmed, Mansoor
dc.contributor.author Gilani, Anwarul-Hassan
dc.date.accessioned 2022-12-06T07:17:20Z
dc.date.available 2022-12-06T07:17:20Z
dc.date.issued 2019-09-20
dc.identifier.citation Hanif, M., Mehmood, M. H., Ishrat, G., Abdullah, A., Sohail, S., Ahmed, M., & Gilani, A. H. (2019). Evaluation of prokinetic and laxative effects of Hippophae rhamnoides in rodents. Pakistan Journal of Pharmaceutical Sciences, 32(5 (Special)), 2527-2533. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14768
dc.description.abstract Hippophae rhamnoides (Family; Elaeagnaceae) fruit extract was investigated for prokinetic and gut excitatory effects to rationalize its therapeutic utility in gastrointestinal complaints like delayed gastric emptying and constipation. The fruit extract of Hippophae rhamnoides (Hr.Cr) prepared in hydro-methanol (30:70) was verified for flavonoids, tannins, coumarins and terpenes as plant constituents. In mice, Hr.Cr administration caused an increased in faecal production and charcoal meal transport (50-300mg/kg, per-oral.), similar to activity pattern of carbamylcholine (1 mg/kg). Laxative and prokinetic effects of Hr.Cr were found partially atropine-sensitive. On challenge with isolated intestinal tissues, Hr.Cr charged a dose-dependent spasmogenic effect on jejunum (0.01-1mg/mL) preparations of rabbit and in ileal tissues (guinea-pig) at the dose range of 0.03 to 3mg/mL, following predominant relaxing impact at increased concentrations. Unlike carbamylcholine, stimulant effect of Hr.Cr was partly antagonized in atropine incubated tissues. These data attest the laxative, prokinetic and gut excitatory activities of Hippophae rhamnoides probably mediated through partial activation of muscarinic receptors. Further in agreement of the current findings with earlier reports on gastric emptying effects of Hippophae rhamnoides seed oil, this is the first study of its kind providing insight into mechanism to the laxative potential of Hippophae rhamnoides fruit, thus rationalizing its medicinal use in constipation. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject H. rhamnoides en_US
dc.subject spasmodic en_US
dc.subject , laxative, prokinetic en_US
dc.subject muscarinic receptor activation en_US
dc.title Evaluation of prokinetic and laxative effects of Hippophae rhamnoides in rodents en_US
dc.type Article en_US


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