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Undiagnosed Hemoglobinopathies: A potential threat to the premarital screening program

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dc.contributor.author Hamali, Hassan A.
dc.contributor.author Saboor, Muhammad
dc.date.accessioned 2019-11-18T10:39:31Z
dc.date.available 2019-11-18T10:39:31Z
dc.date.issued 2019-01-01
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/1477
dc.description.abstract Objectives: To evaluate the prevalence of undiagnosed hemoglobinopathies among individuals visiting the premarital screening Centre. Methods: This study was conducted at Premarital Screening Centre, King Fahad Central Hospital and Research Centre, Jazan, between January 2018 and October 2018. A total of 3,970 (male n =1,859 and female n = 2,111) individuals were included in the study. Data of complete blood count, hemoglobin electrophoresis and sickling tests of all individuals recruited in the study were obtained and statistically analyzed. Results: One thousand three hundred and twelve individuals had abnormal complete blood counts or hemoglobin electrophoresis results, that include sickle cell trait (13.5%), sickle cell disease (0.7%), β thalassemia with sickle cell trait (2.46%), β thalassemia trait (1.51%), β thalassemia major (0.075%), suspected α thalassemia or other hemoglobinopathies (4.43%), hemoglobin H (0.3%), hemoglobin E (0.075%), undiagnosed cases (0.91%) and iron deficient (7.23%). Conclusion: A high percentage of individuals are suspected for α thalassemia or other hemoglobinopathies that needs to be diagnosed. Further investigations shall be included in the premarital screening program to diagnose these inconclusive cases. Coexistence iron deficiency with thalassemia shall also be ruled out during premarital screening program. en_US
dc.language.iso en_US en_US
dc.publisher Pak J Med Sci en_US
dc.subject Medical and Health Sciences en_US
dc.subject Premarital screening en_US
dc.subject Thalassemia en_US
dc.subject Sickle cell anemia en_US
dc.subject Hemoglobinopathy en_US
dc.title Undiagnosed Hemoglobinopathies: A potential threat to the premarital screening program en_US
dc.type Article en_US


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