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In-vitro cytotoxic evaluation, hemolytic and thrombolytic potential of newly designed acefylline based hydrazones as potent anticancer agents against human lung cancer cell line (A549)

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dc.contributor.author Shahzadi, Irum
dc.contributor.author Parveen, Bushra
dc.contributor.author Ahmad, Sajjad
dc.contributor.author Khan, Samreen Gul
dc.contributor.author Zahoor, Ameer Fawad
dc.contributor.author Rasul, Azhar
dc.contributor.author Zahid, Faisal Maqbool
dc.date.accessioned 2022-12-07T04:34:48Z
dc.date.available 2022-12-07T04:34:48Z
dc.date.issued 2022-05-03
dc.identifier.citation Shahzadi, I., Parveen, B., Ahmad, S., Zahoor, A. F., Rasul, A., & Zahid, F. M. (2022). In-vitro cytotoxic evaluation, hemolytic and thrombolytic potential of newly designed acefylline based hydrazones as potent anticancer agents against human lung cancer cell line (A549). Pakistan Journal of Pharmaceutical Sciences, 35(3 (Special)), 885-889. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14802
dc.description.abstract Hydrazones of theophylline-7-acetic acid 5a-g have been synthesized using ultrasonic irradiation as well as conventional heating system and analyzed for their anticancer characteristics against human lung cancer cell line (A549). Compound 5g with cell viability 33.19±0.49% (100 μg/μL) compared to the starting reference drug acefylline having cell viability 86.32±11.75% (100 μg/μL) was found to be the most active anticancer agent among all. The synthesized derivatives were also exposed to hemolytic and thrombolytic studies to determine their cytotoxic profile and results revealed their low toxicity and moderate clot lysis activity. en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Journal of Botany, Botanical Garden, University of Karachi en_US
dc.subject Hydrazones en_US
dc.subject acefylline en_US
dc.subject cell viability en_US
dc.subject hemolytic en_US
dc.subject thrombolytic en_US
dc.title In-vitro cytotoxic evaluation, hemolytic and thrombolytic potential of newly designed acefylline based hydrazones as potent anticancer agents against human lung cancer cell line (A549) en_US
dc.type Article en_US


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