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Appraisal of the pharmacokinetic profile, histopathology, and stability studies of a fast dissolving oral film based on natural polysaccharide

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dc.contributor.author Sheikh, Fatima Akbar
dc.contributor.author Aamir, Muhammad Naeem
dc.contributor.author Haseeb, Muhammad Tahir
dc.contributor.author Shah, Muhammad Ajmal
dc.contributor.author Farid-ul-Haq, Muhammad
dc.contributor.author Alqarni, Muhammad
dc.contributor.author Vargas-De-La-Cruz, Celia
dc.contributor.author Blundell9, Renald
dc.date.accessioned 2022-12-07T05:36:10Z
dc.date.available 2022-12-07T05:36:10Z
dc.date.issued 2022-05-11
dc.identifier.citation Sheikh, F. A., Aamir, M. N., Haseeb, M. T., Shah, M. A., Farid-ul-Haq, M., Alqarni, M., ... & Blundell, R. Appraisal of the pharmacokinetic profile, histopathology, and stability studies of a fast dissolving oral film based on natural polysaccharide. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14817
dc.description.abstract The present research is designed to evaluate the pharmacokinetic profile, histological evaluation, and stability studies of an orodispersible film (ODF) of tizanidine (TZ) and meloxicam (MX) prepared from a natural polysaccharide, i.e., xanthan gum. In vivo release study of TZ and MX was performed in rabbits and results indicated the better pharmacokinetics parameters and improved the oral bioavailability when compared to the oral aqueous suspension and solution of TZ and MX, respectively. The intermediate stability studies were performed at 30±2°C and 65±5% RH, whereas, the accelerated stability studies were carried out at 40±2°C and 75±5% RH, respectively for the duration of six months and results indicated that the ODF was stable for six months without any substantial difference in essential physico-chemical parameters, mechanical attributes, and morphological constraints. The toxicity profile of ODF was determined through histopathology of vital organs after administering the ODF to the rabbits. Histopathology revealed that the tissues of all vital organs are normal and did not exhibit any abnormalities, lesions, or hemorrhage. Therefore, the ODF prepared from xanthan gum exhibited a non-toxic and stable formulation with a better pharmacokinetics profile of MX and TZ. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Polysaccharides en_US
dc.subject solvent casting method en_US
dc.subject polymeric film en_US
dc.subject fast dissolving film en_US
dc.subject orodispersible en_US
dc.title Appraisal of the pharmacokinetic profile, histopathology, and stability studies of a fast dissolving oral film based on natural polysaccharide en_US
dc.type Article en_US


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