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Computational screening of phytochemicals against survivin protein: A potent target for cancer

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dc.contributor.author Hussain, Ghulam
dc.contributor.author Ashfaq, Usman Ali
dc.contributor.author Rahman, Mahmood-ur
dc.contributor.author Masoud, Muhammad Shareef
dc.contributor.author Nahid, Nazia
dc.contributor.author Bhinder, Munir Ahmad
dc.contributor.author Aslam, Nosheen
dc.contributor.author Yousaf, Numan
dc.contributor.author Ahmed, Uzair
dc.contributor.author Qasim, Muhammad
dc.date.accessioned 2022-12-07T06:31:11Z
dc.date.available 2022-12-07T06:31:11Z
dc.date.issued 2019-05-04
dc.identifier.citation Hussain, G., Ashfaq, U. A., Masoud, M. S., Nahid, N., Bhinder, M. A., Aslam, N., ... & Qasim, M. (2019). Computational screening of phytochemicals against survivin protein: A potent target for cancer. Pakistan Journal of Pharmaceutical Sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14829
dc.description.abstract Survivin (IAP proteins) is considered as a significant target for anticancer drug research owing to its upregulation in tumor cells to mediate resistance to apoptotic stimulus. The current study aimed to investigate phytochemicals as inhibitors of survivin with caspases to reactivate the functioning of caspases through molecular docking. The compounds namely 2(R), 4(R)-dihydroxypyrrolidine, 4-hydroxy-2-(4-methoxyphenyl)-1,1-dioxo-3,4- dihydrothieno[3,2-e]thiazine-6-sulfonamide, 2,3-Diketo-L-gulonic acid, (3-hydroxy-2-octadeca-9,12-dienoyloxypropyl) octadecanoate, 2-[[4-[[4-[(4-formamido-1-methylimidazole-2-carbonyl)amino]-1-methylimidazole-2-carbonyl]amino]-1- methylimidazole-2-carbonyl]amino]ethyl-dimethylazanium, Picolinic acid and (2-Hydroxy-5-nitrophenyl) dihydrogen phosphate successfully bind inside the pocket of survivin. ADMETsar was used to evaluate the anticancer potential of selected compounds. These compounds can be proposed as effective inhibitors, disrupting the survivin-caspases interaction and reactivating the caspases function of apoptosis. The study might facilitate the development of costeffective and natural drugs against cancer. However, further validation is essential for confirmation of its drug efficacy and bio-compatibility. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Survivin en_US
dc.subject medicinal plants en_US
dc.subject anticancer drugs en_US
dc.subject computational drug design en_US
dc.title Computational screening of phytochemicals against survivin protein: A potent target for cancer en_US
dc.type Article en_US


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