dc.contributor.author | Zafar, Ansa Madeeha | |
dc.contributor.author | Ashraf, Muhammad | |
dc.contributor.author | Aslam, Samina | |
dc.contributor.author | Naureen, Sadia | |
dc.contributor.author | Aslam, Noreen | |
dc.contributor.author | Jabeen, Mussarat | |
dc.contributor.author | Sajid, Naveed | |
dc.contributor.author | Ghafoor, Abdul | |
dc.contributor.author | Noreen, Shazia | |
dc.contributor.author | Shahi, Mahrzadi Noureen | |
dc.contributor.author | Khan, Misbahul Ain | |
dc.contributor.author | Iqbal, Ambar | |
dc.date.accessioned | 2022-12-07T06:38:27Z | |
dc.date.available | 2022-12-07T06:38:27Z | |
dc.date.issued | 2019-05-04 | |
dc.identifier.citation | Zafar, A. M., Iqbal, A., Ashraf, M., Aslam, S., Naureen, S., Aslam, N., ... & Khan, M. A. (2019). Synthesis and in vitro cholinesterase inhibitory potential of dihydropyridine derivatives. Pakistan Journal of Pharmaceutical Sciences, 32(3 (Supplementary)), 1155-1162. | en_US |
dc.identifier.issn | 1011-601X | |
dc.identifier.uri | http://142.54.178.187:9060/xmlui/handle/123456789/14830 | |
dc.description.abstract | Twelve derivatives of dihydropyridine derivatives (6-17) were synthesized and evaluated for in-vitro cholinesterases (AChE, BChE) inhibitory activity. All compounds showed potent activity with IC50 values between 0.21±0.003 to 147.14±0.12μM for AChE and among them five compounds showed potent activity with IC50 values 17.16±0.02 to 231.6±0.12μM for BChE when compared with standard Eserine (IC50 = 0.85±0.0001 µM (AChE) & 0.04±0.0001µM (BChE). The most potent compound 11 can be considered as potential lead compound showed an inhibition of 95.35±0.11 and IC50= 0.21±0.003 while compound 7 showed an inhibition of 83.45±0.13 and IC50= 17.16±0.02. It is concluded from structural activity relationship that the presence of nitro group at C-2 and C-4 position of dihydropyridine ring increase the acetyl cholinesterase and butyrylcholinesterase activities of these compounds while presence of -Br and -Cl also enhances the activities | en_US |
dc.language.iso | en | en_US |
dc.publisher | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi | en_US |
dc.subject | Dihydropyridines | en_US |
dc.subject | hantzsch reaction | en_US |
dc.subject | MCR | en_US |
dc.subject | alzheimer | en_US |
dc.subject | acetylcholinesterase | en_US |
dc.subject | butyryl-cholinesterase | en_US |
dc.title | Synthesis and in vitro cholinesterase inhibitory potential of dihydropyridine derivatives | en_US |
dc.type | Article | en_US |