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Synthesis and in vitro cholinesterase inhibitory potential of dihydropyridine derivatives

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dc.contributor.author Zafar, Ansa Madeeha
dc.contributor.author Ashraf, Muhammad
dc.contributor.author Aslam, Samina
dc.contributor.author Naureen, Sadia
dc.contributor.author Aslam, Noreen
dc.contributor.author Jabeen, Mussarat
dc.contributor.author Sajid, Naveed
dc.contributor.author Ghafoor, Abdul
dc.contributor.author Noreen, Shazia
dc.contributor.author Shahi, Mahrzadi Noureen
dc.contributor.author Khan, Misbahul Ain
dc.contributor.author Iqbal, Ambar
dc.date.accessioned 2022-12-07T06:38:27Z
dc.date.available 2022-12-07T06:38:27Z
dc.date.issued 2019-05-04
dc.identifier.citation Zafar, A. M., Iqbal, A., Ashraf, M., Aslam, S., Naureen, S., Aslam, N., ... & Khan, M. A. (2019). Synthesis and in vitro cholinesterase inhibitory potential of dihydropyridine derivatives. Pakistan Journal of Pharmaceutical Sciences, 32(3 (Supplementary)), 1155-1162. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14830
dc.description.abstract Twelve derivatives of dihydropyridine derivatives (6-17) were synthesized and evaluated for in-vitro cholinesterases (AChE, BChE) inhibitory activity. All compounds showed potent activity with IC50 values between 0.21±0.003 to 147.14±0.12μM for AChE and among them five compounds showed potent activity with IC50 values 17.16±0.02 to 231.6±0.12μM for BChE when compared with standard Eserine (IC50 = 0.85±0.0001 µM (AChE) & 0.04±0.0001µM (BChE). The most potent compound 11 can be considered as potential lead compound showed an inhibition of 95.35±0.11 and IC50= 0.21±0.003 while compound 7 showed an inhibition of 83.45±0.13 and IC50= 17.16±0.02. It is concluded from structural activity relationship that the presence of nitro group at C-2 and C-4 position of dihydropyridine ring increase the acetyl cholinesterase and butyrylcholinesterase activities of these compounds while presence of -Br and -Cl also enhances the activities en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Dihydropyridines en_US
dc.subject hantzsch reaction en_US
dc.subject MCR en_US
dc.subject alzheimer en_US
dc.subject acetylcholinesterase en_US
dc.subject butyryl-cholinesterase en_US
dc.title Synthesis and in vitro cholinesterase inhibitory potential of dihydropyridine derivatives en_US
dc.type Article en_US


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