Abstract:
The current article discusses the activities of several synthesized metal heterochelates in in-vitro as anti-ulcer
agents followed by their docking study. For this purpose, two important ligands like 8-hydroxyquinoline and DLmethionine were used in synthesis of heterochelates of metal including Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II), Zn (II), Cd (II) and Pb (II). It was observed that these complexes showed excellent urease inhibition activities in which thiourea was the standard having IC50 value 21.6 ± 0.12µM. The Cu (II) complex showed potent inhibitory activity (22.6 ± 0.72 μM) when compared with the standard thiourea (21.6±0.12μM) among the nine synthesized complexes while Mn (II), Fe (III), Cd (II) and Pb (II) also showed better inhibitory activities. The urease inhibitory activities of hetercochelates also tested and validated by docking analysis.