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Heterochelates of metals as an effective anti - Urease agents couple with their docking studies

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dc.contributor.author Qamar, Noshab
dc.contributor.author Sultan, Hira
dc.contributor.author Raheel, Ahmad
dc.contributor.author Ashfaq, Maria
dc.contributor.author Azmat, Rafia
dc.contributor.author Naz, Raheela
dc.contributor.author Lateef, Mehreen
dc.contributor.author Khan, Khalid Mohammed
dc.contributor.author Arshad, Tanzila
dc.date.accessioned 2022-12-07T07:02:40Z
dc.date.available 2022-12-07T07:02:40Z
dc.date.issued 2019-05-08
dc.identifier.citation Qamar, N., Sultan, H., Raheel, A., Ashfaq, M., Azmat, R., Naz, R., ... & Arshad, T. (2019). Heterochelates of metals as an effective anti-Urease agents couple with their docking studies. Pakistan Journal of Pharmaceutical Sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14836
dc.description.abstract The current article discusses the activities of several synthesized metal heterochelates in in-vitro as anti-ulcer agents followed by their docking study. For this purpose, two important ligands like 8-hydroxyquinoline and DLmethionine were used in synthesis of heterochelates of metal including Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II), Zn (II), Cd (II) and Pb (II). It was observed that these complexes showed excellent urease inhibition activities in which thiourea was the standard having IC50 value 21.6 ± 0.12µM. The Cu (II) complex showed potent inhibitory activity (22.6 ± 0.72 μM) when compared with the standard thiourea (21.6±0.12μM) among the nine synthesized complexes while Mn (II), Fe (III), Cd (II) and Pb (II) also showed better inhibitory activities. The urease inhibitory activities of hetercochelates also tested and validated by docking analysis. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Urease en_US
dc.subject inhibition activity en_US
dc.subject complexes en_US
dc.subject docking en_US
dc.title Heterochelates of metals as an effective anti - Urease agents couple with their docking studies en_US
dc.type Article en_US


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