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Assessment of antiviral and antibiotic combination treatment in influenza-A H1N1 induced acute kidney injury among hospitalized patients

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dc.contributor.author Ishaqui, Azfar Athar
dc.contributor.author Sulaiman, Syed Azhar Syed
dc.contributor.author Alsultan, Mohammed Taher
dc.contributor.author Khan, Irfanullah
dc.contributor.author Nami, Hamad Al
dc.date.accessioned 2022-12-07T07:32:28Z
dc.date.available 2022-12-07T07:32:28Z
dc.date.issued 2019-05-15
dc.identifier.citation Ishaqui, A. A., Khan, A. H., Syed Sulaiman, S. A., Alsultan, M. T., Khan, I., & Nami, H. A. (2019). Assessment of antiviral and antibiotic combination treatment in influenza-A H1N1 induced acute kidney injury among hospitalized patients. Pakistan journal of pharmaceutical sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14843
dc.description.abstract The aim of the study is to assess and compare the impact of antiviral drug alone and in combination with antibiotic for prevention of Influenza-A H1N1 induced acute kidney injury (AKI) in hospitalized patients. Hospitalized admitted patients with confirmed diagnosis of Influenza-A H1N1 infection were divided into two groups: group 1, which received antiviral (oseltamivir) drug alone and group 2, which received antiviral (oseltamivir) in combination with empirically prescribed antibiotic. Patients of both groups were assessed for incidences of AKI by two criteria i.e Acute Kidney Injury Network (AKIN) and RIFLE. A total of 329 patients (176 for group 1 and 153 for group 2) were enrolled. According to RIFLE criteria, 23(13%) of group 1 and 9(6%) patients of groups 2 were suffered from AKI with statistically significant difference (P<0.05). Also as per AKIN criteria, the incidence of AKI is statistically significantly difference (P<0.05) between both groups with 18(10%) patients and 6(4%) patients of group 1 and 2 respectively. Length of hospitalization was statistically less (P<0.05) in group 2 patients. The incidences of AKI in Influenza-A H1N1 treated with antiviral and antibiotic combination was statistically less as compared to patients who were given antiviral alone for treatment of influenza infection. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Influenza A en_US
dc.subject H1N1 infection en_US
dc.subject acute kidney injury en_US
dc.subject AKIN en_US
dc.subject RIFLE en_US
dc.title Assessment of antiviral and antibiotic combination treatment in influenza-A H1N1 induced acute kidney injury among hospitalized patients en_US
dc.type Article en_US


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