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Formulation optimization, in vitro characterization and stability studies of sustain release tablets of Ketoprofen

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dc.contributor.author Hafeez, Abdul
dc.contributor.author Razvi, Nighat
dc.contributor.author Talib, Nasira
dc.contributor.author Ghayas, Sana
dc.contributor.author Anjum, Fakhsheena
dc.contributor.author Bushra, Rabia
dc.date.accessioned 2022-12-07T07:37:19Z
dc.date.available 2022-12-07T07:37:19Z
dc.date.issued 2019-05-17
dc.identifier.citation Hafeez, A., Razvi, N., Talib, N., Ghayas, S., Anjum, F., & Bushra, R. (2019). Formulation optimization, in vitro characterization and stability studies of sustain release tablets of Ketoprofen. Pakistan Journal of Pharmaceutical Sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14845
dc.description.abstract The aim of the current study was to formulate sustain release (SR) tablets of ketoprofen. Five batches (batch I -V) of matrix based ketoprofen tablet were prepared by dry granulation method using hydroxyl propyl methyl cellulose (15000cps). Compatibility of formulation excipients with drug was explored through FT-IR technique. Various physical and chemical parameters of all tablet batches were evaluated with multi-point dissolution profile (for 24hrs) for formulation optimization. Release kinetics of trials was estimated by model dependent and independent methods. Formulations having excellent quality attributes were then compared with marketed ketoprofen SR tablets. Accelerated stability study was also conducted to compute the shelf life of the optimized formulation. FT-IR scans illustrated the compatibility of ketoprofen with all tablet excipients. On the basis of testing results and controlled release pattern batch II was set to be an optimized trial having shelf life of 37 months. All trial batches (batch I-V) and the marketed brand exhibited highest linearity towards zero order and Korsmeyer-Peppas model with non-fickian anomalous transport (n=0.541-0.655). en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Ketoprofen en_US
dc.subject sustained release en_US
dc.subject dissolution profile en_US
dc.subject methyl cellulose en_US
dc.title Formulation optimization, in vitro characterization and stability studies of sustain release tablets of Ketoprofen en_US
dc.type Article en_US


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