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Synthesis, lipoxygenase inhibition activity and molecular docking of oxamide derivative

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dc.contributor.author Rehman, Saba Fazal-ur
dc.contributor.author Wasim, Agha Arslan
dc.contributor.author Iqbal, Sadaf
dc.contributor.author Khan, Maria Aqeel
dc.contributor.author Lateef, Mehreen
dc.contributor.author Iqbal, Lubna
dc.date.accessioned 2022-12-07T07:40:04Z
dc.date.available 2022-12-07T07:40:04Z
dc.date.issued 2019-05-18
dc.identifier.citation Fazal-ur-Rehman, S., Wasim, A. A., Iqbal, S., Khan, M. A., Lateef, M., & Iqbal, L. (2019). Synthesis, lipoxygenase inhibition activity and molecular docking of oxamide derivative. Pakistan Journal of Pharmaceutical Sciences, 32(3), 1253-1259. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14846
dc.description.abstract In this study, a range of oxamide ligands were synthesized by the reaction of amines with oxalyl chloride in basic medium. Spectroscopic and analytical techniques such as IR, 1H-NMR and ESI-MS techniques were used for characterization of the synthesized oxamides. The synthesized oxamides were screened for Lipoxygenase inhibition. Biological screening revealed that the oxamides possessed good lipoxygenase inhibition activities, whereas, the unsubstituted oxamide did not show any distinct lipoxygenase inhibition activity. Molecular docking studies of the oxamides were also carried out for lipoxygenase inhibition. The results obtained from molecular docking were well correlated with the empirical data. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Oxamide en_US
dc.subject molecular docking en_US
dc.subject lipoxygenase inhibition en_US
dc.title Synthesis, lipoxygenase inhibition activity and molecular docking of oxamide derivative en_US
dc.type Article en_US


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