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Persistence and safety assessment of novel probiotic strain Lactobacillus plantarum 1 strain Lp86 and Lp36 in Salmonella typhi infected mice

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dc.contributor.author Baloch, Muneera Naz
dc.contributor.author Zafar, Urooj
dc.contributor.author Haider, Fouzia
dc.contributor.author Mojgani, Naheed
dc.contributor.author Eijaz, Sana
dc.contributor.author Siddiqui, Roquya
dc.date.accessioned 2022-12-07T07:43:12Z
dc.date.available 2022-12-07T07:43:12Z
dc.date.issued 2019-05-19
dc.identifier.citation Baloch, M. N., Siddiqui, R., Zafar, U., Haider, F., Mojgani, N., & Eijaz, S. (2019). Persistence and safety assessment of novel probiotic strain Lactobacillus plantarum 1 strain Lp86 and Lp36 in Salmonella typhi infected mice. Pakistan Journal of Pharmaceutical Sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14847
dc.description.abstract The species of Lactic acid bacteria are known to confer beneficial effects on the host by inhabiting in their gastrointestinal tract (GIT). They succeed in surviving the harsh conditions of the GIT by exhibiting strong tolerance against gastric acids, digestive enzymes and bile simultaneously antagonizing the pathogens by production of antimicrobials. This study has been conducted to elaborate these probiotic characteristics in vivo for which mice were intragastrically given a probiotic approved dose of 1011cfu/ml for 4 days to assess the persistence of two probiotic candidates Lactobacillus plantarum Lp36 and Lactobacillus plantarum Lp86. The fecal count of the test probiotic candidates were seen to persist well in the GIT for 15 days with a count ranging between 104 -108 cfu/ mg of feces (p>0.01).The safety assessment of L. plantarum Lp36 in healthy and S. typhi in infected mice showed an increase in cell count from (day zero of inoculation) 106 cfu/100mg of feces to108 cfu/100mg (p>0.01) which was maintained till day six, suggesting the persistence in the GIT. The sections of the mice intestinal lining under scanning electron microscope revealed the adherence of Lp36 and Lp86 to the intestinal epithelia. The mice did not show any adverse effect on its health. These findings make our strains promising probiotic candidates to be used to promote health benefits after further assessments. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Lactobacillus plantarum en_US
dc.subject Probiotics and Lactic acid bacteria en_US
dc.title Persistence and safety assessment of novel probiotic strain Lactobacillus plantarum 1 strain Lp86 and Lp36 in Salmonella typhi infected mice en_US
dc.type Article en_US


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